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10.1155/2018/3405695 http://scihub22266oqcxt.onion/10.1155/2018/3405695 C5944279!5944279 !29854821     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29854821 &cmd=llinks): Failed to open stream: HTTP request failed! 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Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease |pdf=|usr=}}{{29854821 }} gab.com Text Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease JO: J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29854821 #FOAvip BACKGROUND: NADPH oxidase 4 (NOX4) plays a major role in renal oxidative stress of diabetic kidney disease (DKD). NOX4 was significantly increased in Egr1-expressing fibroblasts, but the relationship between Egr1 and NOX4 in DKD is unclear. METHODS: For the evaluation of the potential relationship between Egr1 and NOX4, both were detected in HFD/STZ-induced mice and HK-2 cells treated with TGF-?1. Then, changes in NOX4 expression were detected in HK-2 cells and mice with overexpression and knockdown of Egr1. The direct relationship between Egr1 and NOX4 was explored via chromatin immunoprecipitation (ChIP). RESULTS: We found increased levels of Egr1, NOX4, and ?-SMA in the kidney cortices of diabetic mice and in TGF-?1-treated HK-2 cells. Overexpression or silencing of Egr1 in HK-2 cells could upregulate or downregulate NOX4 and ?-SMA. ChIP assays revealed that TGF-?1 induced Egr1 to bind to the NOX4 promoter. Finally, Egr1 overexpression or knockdown in diabetic mice could upregulate or downregulate the expression of NOX4 and ROS, and ?-SMA was also changed. CONCLUSION: Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to DKD by enhancing EMT, in part by targeting NOX4. Twit Text FOAVip Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease ????J Diabetes Res http://www.kidney.de/pget.php?&tw=1&pmid=29854821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29854821 #FOAvip English Wikipedia <ref>{{Cite pmid|29854821 }}</ref> Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 in Oxidative Stress of Diabetic Kidney Disease #MMPMID29854821 Hu F ; Xue M ; Li Y ; Jia YJ ; Zheng ZJ ; Yang YL ; Guan MP ; Sun L ; Xue YM J Diabetes Res 2018[]; 2018 (ä): 3405695 PMID29854821 show ga BACKGROUND: NADPH oxidase 4 (NOX4) plays a major role in renal oxidative stress of diabetic kidney disease (DKD). NOX4 was significantly increased in Egr1-expressing fibroblasts, but the relationship between Egr1 and NOX4 in DKD is unclear. METHODS: For the evaluation of the potential relationship between Egr1 and NOX4, both were detected in HFD/STZ-induced mice and HK-2 cells treated with TGF-?1. Then, changes in NOX4 expression were detected in HK-2 cells and mice with overexpression and knockdown of Egr1. The direct relationship between Egr1 and NOX4 was explored via chromatin immunoprecipitation (ChIP). RESULTS: We found increased levels of Egr1, NOX4, and ?-SMA in the kidney cortices of diabetic mice and in TGF-?1-treated HK-2 cells. Overexpression or silencing of Egr1 in HK-2 cells could upregulate or downregulate NOX4 and ?-SMA. ChIP assays revealed that TGF-?1 induced Egr1 to bind to the NOX4 promoter. Finally, Egr1 overexpression or knockdown in diabetic mice could upregulate or downregulate the expression of NOX4 and ROS, and ?-SMA was also changed. CONCLUSION: Our study provides strong evidence that Egr1 is a transcriptional activator of NOX4 in oxidative stress of DKD. Egr1 contributes to DKD by enhancing EMT, in part by targeting NOX4. |Actins/genetics/metabolism [MESH] |Animals [MESH] |Cell Line [MESH] |Diabetes Mellitus, Experimental/genetics/*metabolism [MESH] |Diabetic Nephropathies/genetics/*metabolism [MESH] |Down-Regulation/drug effects [MESH] |Early Growth Response Protein 1/genetics/*metabolism [MESH] |Kidney/drug effects/metabolism [MESH] |Male [MESH] |Mice [MESH] |NADPH Oxidase 4/genetics/*metabolism [MESH] |Oxidative Stress/drug effects/*physiology [MESH] |Promoter Regions, Genetic [MESH] |Reactive Oxygen Species/metabolism [MESH] |Signal Transduction/drug effects [MESH] |Transforming Growth Factor beta1/pharmacology [MESH]Early Growth Response 1 (Egr1) Is a Transcriptional Activator of NOX4 (epmc).pdf DeepDyve Pubget Overpricing