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10.1155/2018/1243858

http://scihub22266oqcxt.onion/10.1155/2018/1243858
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C5944193!5944193!29854718
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suck abstract from ncbi


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pmid29854718      Int+J+Genomics 2018 ; 2018 (ä): ä
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  • Characterization of Transcription Termination-Associated RNAs: New Insights into their Biogenesis, Tailing, and Expression in Primary Tumors #MMPMID29854718
  • Laudadio I; Formichetti S; Gioiosa S; Klironomos F; Rajewsky N; Macino G; Carissimi C; Fulci V
  • Int J Genomics 2018[]; 2018 (ä): ä PMID29854718show ga
  • Next-generation sequencing has uncovered novel classes of small RNAs (sRNAs) in eukaryotes, in addition to the well-known miRNAs, siRNAs, and piRNAs. In particular, sRNA species arise from transcription start sites (TSSs) and the transcription termination sites (TTSs) of genes. However, a detailed characterization of these new classes of sRNAs is still lacking. Here, we present a comprehensive study of sRNAs derived from TTSs of expressed genes (TTSa-RNAs) in human cell lines and primary tissues. Taking advantage of sRNA-sequencing, we show that TTSa-RNAs are present in the nuclei of human cells, are loaded onto both AGO1 and AGO2, and their biogenesis does not require DICER and AGO2 endonucleolytic activity. TTSa-RNAs display a strong bias against a G residue in the first position at 5? end, a known feature of AGO-bound sRNAs, and a peculiar oligoA tail at 3? end. AGO-bound TTSa-RNAs derive from genes involved in cell cycle progression regulation and DNA integrity checkpoints. Finally, we provide evidence that TTSa-RNAs can be detected by sRNA-Seq in primary human tissue, and their expression increases in tumor samples as compared to nontumor tissues, suggesting that in the future, TTSa-RNAs might be explored as biomarker for diagnosis or prognosis of human malignancies.
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