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10.1177/2374289518766521

http://scihub22266oqcxt.onion/10.1177/2374289518766521
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C5944141!5944141!29761157
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suck abstract from ncbi


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pmid29761157      Acad+Pathol 2018 ; 5 (ä): ä
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  • A Next-Generation Sequencing Primer?How Does It Work and What Can It Do? #MMPMID29761157
  • Alekseyev YO; Fazeli R; Yang S; Basran R; Maher T; Miller NS; Remick D
  • Acad Pathol 2018[Jan]; 5 (ä): ä PMID29761157show ga
  • Next-generation sequencing refers to a high-throughput technology that determines the nucleic acid sequences and identifies variants in a sample. The technology has been introduced into clinical laboratory testing and produces test results for precision medicine. Since next-generation sequencing is relatively new, graduate students, medical students, pathology residents, and other physicians may benefit from a primer to provide a foundation about basic next-generation sequencing methods and applications, as well as specific examples where it has had diagnostic and prognostic utility. Next-generation sequencing technology grew out of advances in multiple fields to produce a sophisticated laboratory test with tremendous potential. Next-generation sequencing may be used in the clinical setting to look for specific genetic alterations in patients with cancer, diagnose inherited conditions such as cystic fibrosis, and detect and profile microbial organisms. This primer will review DNA sequencing technology, the commercialization of next-generation sequencing, and clinical uses of next-generation sequencing. Specific applications where next-generation sequencing has demonstrated utility in oncology are provided.
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