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10.1038/aps.2018.5 http://scihub22266oqcxt.onion/10.1038/aps.2018.5 C5943917!5943917!29565039     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29565039&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acta+Pharmacol+Sin 2018 ; 39 (5): 661-8 Nephropedia Template TP {{tp|p=29565039|t=2018. Discovery and development of NA-1 for the treatment of acute ischemic stroke |pdf=|usr=}}{{29565039}} gab.com Text Discovery and development of NA-1 for the treatment of acute ischemic stroke JO: Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=29565039 #FOAvip Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. In this review we describe its signaling cascade, the target of its therapeutic intervention and its translation from bench to clinical trial. Twit Text FOAVip Discovery and development of NA-1 for the treatment of acute ischemic stroke ????Acta Pharmacol Sin http://www.kidney.de/pget.php?&tw=1&pmid=29565039 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29565039 #FOAvip English Wikipedia <ref>{{Cite pmid|29565039}}</ref> Discovery and development of NA-1 for the treatment of acute ischemic stroke #MMPMID29565039 Ballarin B; Tymianski M Acta Pharmacol Sin 2018[May]; 39 (5): 661-8 PMID29565039show ga Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke. In this review we describe its signaling cascade, the target of its therapeutic intervention and its translation from bench to clinical trial. äDiscovery and development of NA-1 for the treatment of acute ischemic (epmc).pdf DeepDyve Pubget Overpricing