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10.3904/kjim.2016.131 http://scihub22266oqcxt.onion/10.3904/kjim.2016.131 C5943651!5943651!28298077     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Korean+J+Intern+Med 2018 ; 33 (3): 568-76 Nephropedia Template TP {{tp|p=28298077|t=2018. Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys |pdf=|usr=}}{{28298077}} gab.com Text Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys JO: Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=28298077 #FOAvip Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral ureteral obstruction (UUO) model. Methods: Thirty-six Sprague-Dawley rats were randomly assigned into six groups. Two sham groups were divided into a vehicle-treated or colchicine-treated group (100 ?g/kg/day). Four UUO groups were treated with either vehicle or three different doses of colchicine for 7 days (30, 60, and 100 ?g/kg/day, intraperitoneally). All of the animals were sacrificed on day 7. Results: Colchicine treatment diminished acetylated ?-tubulin and tumor growth factor-? immunoreactivities in the cortical area of the 7-day obstructed kidneys, which was in dose dependent manner. Colchicine attenuated tubulointerstitial damage and apoptosis in both cortical and medullary area, and beneficial effects of colchicine therapy were dramatically shown at the higher dosage of colchicine. The expression levels of cleaved caspase-3, ED-1, and fibronectin were decreased in UUO animals. Conclusions: We found that the proper dosage of colchicine may have anti-fibrotic and anti-apoptotic effects in obstructed kidneys. For clinical applications, an optimal dose of colchicine should be evaluated to maximize the prevention of renal disease progression. Twit Text FOAVip Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys ????Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=28298077 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28298077 #FOAvip English Wikipedia <ref>{{Cite pmid|28298077}}</ref> Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys #MMPMID28298077 Kim S; Jung ES; Lee J; Heo NJ; Na KY; Han JS Korean J Intern Med 2018[May]; 33 (3): 568-76 PMID28298077show ga Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral ureteral obstruction (UUO) model. Methods: Thirty-six Sprague-Dawley rats were randomly assigned into six groups. Two sham groups were divided into a vehicle-treated or colchicine-treated group (100 ?g/kg/day). Four UUO groups were treated with either vehicle or three different doses of colchicine for 7 days (30, 60, and 100 ?g/kg/day, intraperitoneally). All of the animals were sacrificed on day 7. Results: Colchicine treatment diminished acetylated ?-tubulin and tumor growth factor-? immunoreactivities in the cortical area of the 7-day obstructed kidneys, which was in dose dependent manner. Colchicine attenuated tubulointerstitial damage and apoptosis in both cortical and medullary area, and beneficial effects of colchicine therapy were dramatically shown at the higher dosage of colchicine. The expression levels of cleaved caspase-3, ED-1, and fibronectin were decreased in UUO animals. Conclusions: We found that the proper dosage of colchicine may have anti-fibrotic and anti-apoptotic effects in obstructed kidneys. For clinical applications, an optimal dose of colchicine should be evaluated to maximize the prevention of renal disease progression. äEffects of colchicine on renal fibrosis and apoptosis in obstructed ki(epmc).pdf DeepDyve Pubget Overpricing