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10.1038/s41598-018-25674-4 http://scihub22266oqcxt.onion/10.1038/s41598-018-25674-4 C5943318!5943318 !29743665     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29743665 &cmd=llinks): Failed to open stream: HTTP request failed! 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Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis |pdf=|usr=}}{{29743665 }} gab.com Text Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29743665 #FOAvip Chronic kidney disease is characterized by prolonged decline in renal function, excessive accumulation of ECM, and progressive tissue fibrosis. Transglutaminase (TG) is a crosslinking enzyme that catalyzes the formation of covalent bonds between glutamine and lysine residues, and is involved in the induction of renal fibrosis via the stabilization of ECM and the activation of TGF-?1. Despite the accumulating evidences indicating that TG2 is a key enzyme in fibrosis, genetic knockout of TG2 reduced by only 50% the elevated protein crosslinking and fibrous protein in renal fibrosis model, whereas treatment with TG inhibitor almost completely reduced these levels. Here, we also clarified the distributions of TG isozymes and their in situ activities and identified the isozyme-specific crosslinked substrates for both TG1 and TG2 in fibrotic kidney. We found that TG1 activity was markedly enhanced in renal tubular epithelium and interstitial areas, whereas TG2 activity increased only in the extracellular space. In total, 47 and 67 possible candidates were identified as TG1 and TG2 substrates, respectively, only in fibrotic kidney. Among them, several possible substrates related to renal disease and fibrosis were identified. These findings provide novel insights into the mechanisms of renal fibrosis through the targeting of isozyme-specific TG substrates. Twit Text FOAVip Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29743665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29743665 #FOAvip English Wikipedia <ref>{{Cite pmid|29743665 }}</ref> Isozyme-specific comprehensive characterization of transglutaminase-crosslinked substrates in kidney fibrosis #MMPMID29743665 Tatsukawa H ; Otsu R ; Tani Y ; Wakita R ; Hitomi K Sci Rep 2018[May]; 8 (1 ): 7306 PMID29743665 show ga Chronic kidney disease is characterized by prolonged decline in renal function, excessive accumulation of ECM, and progressive tissue fibrosis. Transglutaminase (TG) is a crosslinking enzyme that catalyzes the formation of covalent bonds between glutamine and lysine residues, and is involved in the induction of renal fibrosis via the stabilization of ECM and the activation of TGF-?1. Despite the accumulating evidences indicating that TG2 is a key enzyme in fibrosis, genetic knockout of TG2 reduced by only 50% the elevated protein crosslinking and fibrous protein in renal fibrosis model, whereas treatment with TG inhibitor almost completely reduced these levels. Here, we also clarified the distributions of TG isozymes and their in situ activities and identified the isozyme-specific crosslinked substrates for both TG1 and TG2 in fibrotic kidney. We found that TG1 activity was markedly enhanced in renal tubular epithelium and interstitial areas, whereas TG2 activity increased only in the extracellular space. In total, 47 and 67 possible candidates were identified as TG1 and TG2 substrates, respectively, only in fibrotic kidney. Among them, several possible substrates related to renal disease and fibrosis were identified. These findings provide novel insights into the mechanisms of renal fibrosis through the targeting of isozyme-specific TG substrates. |Animals [MESH] |Biomarkers/metabolism [MESH] |Fibrosis [MESH] |GTP-Binding Proteins/genetics/*metabolism [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Kidney/*enzymology/*pathology [MESH] |Mice [MESH] |Protein Glutamine gamma Glutamyltransferase 2 [MESH] |Protein Transport [MESH]Isozyme-specific comprehensive characterization of transglutaminase-cr(epmc).pdf DeepDyve Pubget Overpricing