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10.1016/bs.ctdb.2016.11.001 http://scihub22266oqcxt.onion/10.1016/bs.ctdb.2016.11.001 C5943083!5943083!28236972     free     free     free       Curr+Top+Dev+Biol 2017 ; 123 (ä): 365-97 Nephropedia Template TP {{tp|p=28236972|t=2017. Regulation of cell polarity by PAR-1/MARK kinase |pdf=|usr=}}{{28236972}} gab.com Text Regulation of cell polarity by PAR-1/MARK kinase JO: Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators of cell polarity. PAR-1/MARK kinases localize and function in opposition to the Anterior PAR proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In this review, we discuss the mechanisms that control the localization and activity of PAR-1/MARK kinases, including their antagonistic interactions with the Anterior PAR proteins. We focus on the role PAR-1 plays in the asymmetric division of the C. elegans zygote, in the establishment of the anterior/posterior axis in the Drosophila oocyte and in the control of microtubule dynamics in mammalian neurons. In addition to conserved aspects of PAR-1 biology, we highlight the unique ways in which PAR-1 acts in these distinct cell types to orchestrate their polarization. Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer?s disease and cancer. Twit Text FOAVip Regulation of cell polarity by PAR-1/MARK kinase ????Curr Top Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28236972 #FOAvip English Wikipedia <ref>{{Cite pmid|28236972}}</ref> Regulation of cell polarity by PAR-1/MARK kinase #MMPMID28236972 Wu Y; Griffin EE Curr Top Dev Biol 2017[]; 123 (ä): 365-97 PMID28236972show ga PAR-1/MARK kinases are conserved serine/threonine kinases that are essential regulators of cell polarity. PAR-1/MARK kinases localize and function in opposition to the Anterior PAR proteins to control the asymmetric distribution of factors in a wide variety polarized cells. In this review, we discuss the mechanisms that control the localization and activity of PAR-1/MARK kinases, including their antagonistic interactions with the Anterior PAR proteins. We focus on the role PAR-1 plays in the asymmetric division of the C. elegans zygote, in the establishment of the anterior/posterior axis in the Drosophila oocyte and in the control of microtubule dynamics in mammalian neurons. In addition to conserved aspects of PAR-1 biology, we highlight the unique ways in which PAR-1 acts in these distinct cell types to orchestrate their polarization. Finally, we review the connections between disruptions in PAR-1/MARK function and Alzheimer?s disease and cancer. äRegulation of cell polarity by PAR-1/MARK kinase (epmc).pdf DeepDyve Pubget Overpricing