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2018 ; 10
(ä): 33-42
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gab.com Text
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Grazoprevir/elbasvir for the treatment of adults with chronic hepatitis C: a
short review on the clinical evidence and place in therapy
#MMPMID29765256
Sulejmani N
; Jafri SM
Hepat Med
2018[]; 10
(ä): 33-42
PMID29765256
show ga
Chronic hepatitis C virus (HCV) infection impacts approximately 71 million people
and approximately 400,000 deaths are attributed to HCV-related liver disease
annually worldwide. Mainstay of treatment for over 25 years has been pegylated
interferon until the advent of protease inhibitors, which has led to all-oral HCV
treatment regimens that have changed the outlook of hepatitis C treatment.
Grazoprevir/elbasvir provides high rates of efficacy and tolerability and is an
all-oral once daily treatment option for HCV infection. Efficacy of
grazoprevir/elbasvir has been proven in patients with cirrhosis, patients who
have previously failed treatment with peginterferon and ribavirin (RBV), patients
with end-stage renal disease and patients with HIV co-infection. Data have shown
a high barrier to resistance despite the presence of resistance-associated
substitutions. Grazoprevir/elbasvir represents a very promising regimen for
treatment of HCV infection. This review provides a summary of pharmacology,
efficacy, and safety of grazoprevir/elbasvir for the treatment of HCV infection.