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10.5811/westjem.2017.12.36174

http://scihub22266oqcxt.onion/10.5811/westjem.2017.12.36174
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suck abstract from ncbi


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pmid29760856
      West+J+Emerg+Med 2018 ; 19 (3 ): 559-566
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  • Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department #MMPMID29760856
  • Motov S ; Drapkin J ; Likourezos A ; Beals T ; Monfort R ; Fromm C ; Marshall J
  • West J Emerg Med 2018[May]; 19 (3 ): 559-566 PMID29760856 show ga
  • INTRODUCTION: Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED). METHODS: We conducted a retrospective chart review of patients aged 18 and older presenting to the ED with acute and chronic painful conditions who received continuous SDK infusion in the ED for a period over six years (2010-2016). Primary data analyses included dosing and duration of infusion, rates of pre- and post-infusion analgesic administration, and final diagnoses. Secondary data included pre- and post-infusion pain scores and rates of side effects. RESULTS: A total of 104 patients were enrolled in the study. Average dosing of SDK infusion was 11.26 mg/hr, and the mean duration of infusion was 135.87 minutes. There was a 38% increase in patients not requiring post-infusion analgesia. The average decrease in pain score was 5.04. There were 12 reported adverse effects, with nausea being the most prevalent. CONCLUSION: Continuous intravenous SDK infusion has a role in controlling pain of various etiologies in the ED with a potential to reduce the need for co-analgesics or rescue analgesic administration. There is a need for more robust, prospective, randomized trials that will further evaluate the analgesic efficacy and safety of this modality across a wide range of pain syndromes and different age groups in the ED.
  • |*Administration, Intravenous [MESH]
  • |*Emergency Service, Hospital [MESH]
  • |Analgesics/*therapeutic use [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Ketamine/*administration & dosage/adverse effects [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Pain Management/*methods [MESH]
  • |Pain/*drug therapy [MESH]


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