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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 West+J+Emerg+Med
2018 ; 19
(3
): 559-566
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Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain
in the Emergency Department
#MMPMID29760856
Motov S
; Drapkin J
; Likourezos A
; Beals T
; Monfort R
; Fromm C
; Marshall J
West J Emerg Med
2018[May]; 19
(3
): 559-566
PMID29760856
show ga
INTRODUCTION: Our objective was to describe dosing, duration, and pre- and
post-infusion analgesic administration of continuous intravenous sub-dissociative
dose ketamine (SDK) infusion for managing a variety of painful conditions in the
emergency department (ED). METHODS: We conducted a retrospective chart review of
patients aged 18 and older presenting to the ED with acute and chronic painful
conditions who received continuous SDK infusion in the ED for a period over six
years (2010-2016). Primary data analyses included dosing and duration of
infusion, rates of pre- and post-infusion analgesic administration, and final
diagnoses. Secondary data included pre- and post-infusion pain scores and rates
of side effects. RESULTS: A total of 104 patients were enrolled in the study.
Average dosing of SDK infusion was 11.26 mg/hr, and the mean duration of infusion
was 135.87 minutes. There was a 38% increase in patients not requiring
post-infusion analgesia. The average decrease in pain score was 5.04. There were
12 reported adverse effects, with nausea being the most prevalent. CONCLUSION:
Continuous intravenous SDK infusion has a role in controlling pain of various
etiologies in the ED with a potential to reduce the need for co-analgesics or
rescue analgesic administration. There is a need for more robust, prospective,
randomized trials that will further evaluate the analgesic efficacy and safety of
this modality across a wide range of pain syndromes and different age groups in
the ED.