Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27733490
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27733490
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ther+Adv+Respir+Dis
2017 ; 11
(1
): 64-72
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Therapeutic management of patients with rheumatoid arthritis and associated
interstitial lung disease: case report and literature review
#MMPMID27733490
Picchianti Diamanti A
; Markovic M
; Argento G
; Giovagnoli S
; Ricci A
; Laganą B
; D'Amelio R
Ther Adv Respir Dis
2017[Jan]; 11
(1
): 64-72
PMID27733490
show ga
Rheumatoid arthritis (RA) is an inflammatory autoimmune disease that can present
different extrarticular manifestations involving heart, lungs and kidneys. In
recent years there has been a growing awareness of the central role played by the
lungs in the onset and progression of RA. In particular interstitial lung disease
(ILD) is a common pulmonary manifestation that may be related to the inflammatory
process itself, infectious complications and to the treatments used. Management
of patients with ILD/RA is still a challenge for clinicians, both synthetic
[mainly methotrexate (MTX), leflunomide] and biologic immunosuppressors [mainly
anti-tumor necrosis factor (TNF)?] have in fact been related to the onset or
worsening of lung diseases with conflicting data. Here we report the case of a
61-year-old male patient with severely active early RA, previously treated with
MTX, who developed subacute ILD, along with a review of ILD/RA topic. Tocilizumab
(humanized monoclonal antibody against the interleukin-6 receptor) was introduced
on the basis of its effectiveness in RA without concomitant MTX and the ability
to overcome the profibrotic effects of interleukin (IL)-6. After 3 months of
treatment the clinical condition of the patient strongly improved until it
reached low disease activity. He no longer complained of cough and dyspnea and
bilateral basal crackles were no more present. Considering its distinctive
features, tocilizumab, in such a challenging clinical condition, appears to be a
safe and effective therapy, thus it enables RA remission without deteriorating
ILD, at 1-year follow up, as confirmed by ultrasonography of the affected joints
and chest high-resolution computed tomography (HRCT).
|Antibodies, Monoclonal, Humanized/*therapeutic use
[MESH]