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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Future+Cardiol 2017 ; 13 (3): 279-96 Nephropedia Template TP
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PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease Part II: PPAR-?/? and PPAR-? #MMPMID28581362
Han L; Shen WJ; Bittner S; Kraemer FB; Azhar S
Future Cardiol 2017[May]; 13 (3): 279-96 PMID28581362show ga
The PPARs are a subfamily of three ligand-inducible transcription factors, which belong to the superfamily of nuclear hormone receptors. In mammals, the PPAR subfamily consists of three members: PPAR-?, PPAR-?/? and PPAR-?. PPARs control the expression of a large number of genes involved in metabolic homeostasis, lipid, glucose and energy metabolism, adipogenesis and inflammation. PPARs regulate a large number of metabolic pathways that are implicated in the pathogenesis of metabolic diseases such as metabolic syndrome, Type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular disease. The aim of this review is to provide up-to-date information about the biochemical and metabolic actions of PPAR-?/? and PPAR-?, the therapeutic potential of their agonists currently under clinical development and the cardiovascular disease outcome of clinical trials of PPAR-? agonists, pioglitazone and rosiglitazone.