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10.1038/s41598-018-25370-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-25370-3 C5940888!5940888 !29739987     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 278.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29739987 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 7276 Nephropedia Template TP {{tp|p=29739987 |t=2018. Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves orbital fibroblasts |pdf=|usr=}}{{29739987 }} gab.com Text Essential role of connective tissue growth factor (CTGF) in transforming growth factor- 1 (TGF- 1)-induced myofibroblast transdifferentiation from Graves orbital fibroblasts JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29739987 #FOAvip Connective tissue growth factor (CTGF) associated with transforming growth factor-? (TGF-?) play a pivotal role in the pathophysiology of many fibrotic disorders. However, it is not clear whether this interaction also takes place in GO. In this study, we investigated the role of CTGF in TGF-?-induced extracellular matrix production and myofibroblast transdifferentiation in Graves' orbital fibroblasts. By Western blot analysis, we demonstrated that TGF-?1 induced the expression of CTGF, fibronectin, and alpha-smooth muscle actin (?-SMA) in Graves' orbital fibroblasts. In addition, the protein levels of fibronectin and ?-SMA in Graves' orbital fibroblasts were also increased after treatment with a recombinant human protein CTGF (rhCTGF). Moreover, we transfected the orbital fibroblasts with a small hairpin RNA of CTGF gene (shCTGF) to knockdown the expression levels of CTGF, which showed that knockdown of CTGF significantly diminished TGF-?1-induced expression of CTGF, fibronectin and ?-SMA proteins in Graves' orbital fibroblasts. Furthermore, the addition of rhCTGF to the shCTGF-transfected orbital fibroblasts could restore TGF-?1-induced expression of fibronectin and ?-SMA proteins. Our findings demonstrate that CTGF is an essential downstream mediator for TGF-?1-induced extracellular matrix production and myofibroblast transdifferentiation in Graves' orbital fibroblasts and thus may provide with a potential therapeutic target for treatment of GO. Twit Text FOAVip Essential role of connective tissue growth factor (CTGF) in transforming growth factor- 1 (TGF- 1)-induced myofibroblast transdifferentiation from Graves orbital fibroblasts ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29739987 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29739987 #FOAvip English Wikipedia <ref>{{Cite pmid|29739987 }}</ref> Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves orbital fibroblasts #MMPMID29739987 Tsai CC ; Wu SB ; Kau HC ; Wei YH Sci Rep 2018[May]; 8 (1 ): 7276 PMID29739987 show ga Connective tissue growth factor (CTGF) associated with transforming growth factor-? (TGF-?) play a pivotal role in the pathophysiology of many fibrotic disorders. However, it is not clear whether this interaction also takes place in GO. In this study, we investigated the role of CTGF in TGF-?-induced extracellular matrix production and myofibroblast transdifferentiation in Graves' orbital fibroblasts. By Western blot analysis, we demonstrated that TGF-?1 induced the expression of CTGF, fibronectin, and alpha-smooth muscle actin (?-SMA) in Graves' orbital fibroblasts. In addition, the protein levels of fibronectin and ?-SMA in Graves' orbital fibroblasts were also increased after treatment with a recombinant human protein CTGF (rhCTGF). Moreover, we transfected the orbital fibroblasts with a small hairpin RNA of CTGF gene (shCTGF) to knockdown the expression levels of CTGF, which showed that knockdown of CTGF significantly diminished TGF-?1-induced expression of CTGF, fibronectin and ?-SMA proteins in Graves' orbital fibroblasts. Furthermore, the addition of rhCTGF to the shCTGF-transfected orbital fibroblasts could restore TGF-?1-induced expression of fibronectin and ?-SMA proteins. Our findings demonstrate that CTGF is an essential downstream mediator for TGF-?1-induced extracellular matrix production and myofibroblast transdifferentiation in Graves' orbital fibroblasts and thus may provide with a potential therapeutic target for treatment of GO. |Actins/genetics [MESH] |Adult [MESH] |Cell Transdifferentiation/*genetics [MESH] |Cells, Cultured [MESH] |Connective Tissue Growth Factor/*genetics [MESH] |Female [MESH] |Fibroblasts/metabolism/pathology [MESH] |Gene Expression Regulation/genetics [MESH] |Graves Ophthalmopathy/*genetics/physiopathology [MESH] |Humans [MESH] |Male [MESH] |Myofibroblasts/metabolism [MESH] |Orbit/pathology [MESH]Essential role of connective tissue growth factor (CTGF) in transformi(epmc).pdf DeepDyve Pubget Overpricing