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10.1038/s41467-018-04134-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-04134-7 C5940870!5940870 !29739946     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29739946 &cmd=llinks): Failed to open stream: HTTP request failed! 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NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells |pdf=|usr=}}{{29739946 }} gab.com Text NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29739946 #FOAvip NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage of vascular endothelial cells with hemogenic potential. However, the role of NOTCH signaling in hemogenic endothelium (HE) specification from human pluripotent stem cell (hPSC) has not been studied. Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144(+)CD43(-)CD73(-)DLL4(+)Runx1?+?23-GFP(+) arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells. These findings demonstrate that NOTCH-mediated arterialization of HE is an essential prerequisite for establishing definitive lympho-myeloid program and suggest that exploring molecular pathways that lead to arterial specification may aid in vitro approaches to enhance definitive hematopoiesis from hPSCs. Twit Text FOAVip NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29739946 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29739946 #FOAvip English Wikipedia <ref>{{Cite pmid|29739946 }}</ref> NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells #MMPMID29739946 Uenishi GI ; Jung HS ; Kumar A ; Park MA ; Hadland BK ; McLeod E ; Raymond M ; Moskvin O ; Zimmerman CE ; Theisen DJ ; Swanson S ; J Tamplin O ; Zon LI ; Thomson JA ; Bernstein ID ; Slukvin II Nat Commun 2018[May]; 9 (1 ): 1828 PMID29739946 show ga NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage of vascular endothelial cells with hemogenic potential. However, the role of NOTCH signaling in hemogenic endothelium (HE) specification from human pluripotent stem cell (hPSC) has not been studied. Here, using a chemically defined hPSC differentiation system combined with the use of DLL1-Fc and DAPT to manipulate NOTCH, we discover that NOTCH activation in hPSC-derived immature HE progenitors leads to formation of CD144(+)CD43(-)CD73(-)DLL4(+)Runx1?+?23-GFP(+) arterial-type HE, which requires NOTCH signaling to undergo endothelial-to-hematopoietic transition and produce definitive lympho-myeloid and erythroid cells. These findings demonstrate that NOTCH-mediated arterialization of HE is an essential prerequisite for establishing definitive lympho-myeloid program and suggest that exploring molecular pathways that lead to arterial specification may aid in vitro approaches to enhance definitive hematopoiesis from hPSCs. |*Hematopoiesis [MESH] |*Neovascularization, Physiologic [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Antigens, CD/immunology [MESH] |Arteries/*cytology/metabolism [MESH] |Calcium-Binding Proteins [MESH] |Cell Differentiation [MESH] |Cell Line [MESH] |Cell Lineage [MESH] |Cell Tracking/instrumentation [MESH] |Coculture Techniques [MESH] |Embryo, Mammalian/cytology [MESH] |Endothelium, Vascular/*cytology/metabolism [MESH] |Erythroid Precursor Cells/cytology/immunology [MESH] |Hemangioblasts/*cytology/immunology [MESH] |Hematopoietic Stem Cells/metabolism [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/metabolism [MESH] |Lymphoid Progenitor Cells/cytology/immunology [MESH] |Membrane Proteins/metabolism [MESH] |Mice [MESH] |Myeloid Progenitor Cells/cytology/immunology [MESH] |Pluripotent Stem Cells/*cytology/immunology [MESH]NOTCH signaling specifies arterial-type definitive hemogenic endotheli(epmc).pdf DeepDyve Pubget Overpricing