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10.1016/j.yjmcc.2018.03.004 http://scihub22266oqcxt.onion/10.1016/j.yjmcc.2018.03.004 C5940552!5940552 !29526491     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29526491 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Cell+Cardiol 2018 ; 118 (ä): 70-80 Nephropedia Template TP {{tp|p=29526491 |t=2018. Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction |pdf=|usr=}}{{29526491 }} gab.com Text Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction JO: J Mol Cell Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=29526491 #FOAvip 12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular remodeling is unclear. To determine the role of 12/15LOX, 8-12?week-old C57BL/6?J wild-type (WT; n?=?93) and 12/15LOX(-/-) (n?=?97) mice were subjected to permanent coronary artery ligation and monitored at day (d)1 and d5 post-operatively. Post-MI d28 survival was measured in male and female mice. No-MI surgery mice were maintained as d0 naïve controls. 12/15LOX(-/-) mice exhibited higher survival rates with lower cardiac rupture and improved LV function as compared with WT post-MI. Compared to WT, neutrophils and macrophages in 12/15LOX(-/-) mice were polarized towards N2 and M2 phenotypes, respectively, with increased of expression mrc-1, ym-1, and arg-1 post-MI. 12/15LOX(-/-) mice exhibited lower levels of pro-inflammatory 12-(S)-hydroperoxyeicosatetraenoic acid (12(S)-HETE) and higher CYP2J-derived epoxyeicosatrienoic acids (EETs) levels. CYP2J-derived 5,6-, 8,9-, 11,12-, and 14,15-EETs activated macrophage-specific hemeoxygenase (HO)-1 marked with increases in F4/80(+)/Ly6C(low) and F4/80(+)/CD206(high) cells at d5 post-MI in 12/15LOX(-/-) mice. In contrast, inhibition of HO-1 led to total mortality in 12/15LOX(-/-) mice by post-MI d5. 12/15LOX(-/-) mice exhibited reduced collagen density and lower ?-smooth muscle actin (SMA) expression at d5 post-MI, indicating delayed or limited fibroblast-to-myofibroblast differentiation. In conclusion, genetic deletion of 12/15LOX reduces 12(S)-HETE and activates CYP2J-derived EETs to promote effective resolution of inflammation post-MI leading to reduced cardiac rupture, improved LV function, and better survival. Twit Text FOAVip Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction ????J Mol Cell Cardiol http://www.kidney.de/pget.php?&tw=1&pmid=29526491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29526491 #FOAvip English Wikipedia <ref>{{Cite pmid|29526491 }}</ref> Genetic deletion of 12/15 lipoxygenase promotes effective resolution of inflammation following myocardial infarction #MMPMID29526491 Kain V ; Ingle KA ; Kabarowski J ; Barnes S ; Limdi NA ; Prabhu SD ; Halade GV J Mol Cell Cardiol 2018[May]; 118 (ä): 70-80 PMID29526491 show ga 12/15 lipoxygenase (LOX) directs inflammation and lipid remodeling. However, the role of 12/15LOX in post-myocardial infarction (MI) left ventricular remodeling is unclear. To determine the role of 12/15LOX, 8-12?week-old C57BL/6?J wild-type (WT; n?=?93) and 12/15LOX(-/-) (n?=?97) mice were subjected to permanent coronary artery ligation and monitored at day (d)1 and d5 post-operatively. Post-MI d28 survival was measured in male and female mice. No-MI surgery mice were maintained as d0 naïve controls. 12/15LOX(-/-) mice exhibited higher survival rates with lower cardiac rupture and improved LV function as compared with WT post-MI. Compared to WT, neutrophils and macrophages in 12/15LOX(-/-) mice were polarized towards N2 and M2 phenotypes, respectively, with increased of expression mrc-1, ym-1, and arg-1 post-MI. 12/15LOX(-/-) mice exhibited lower levels of pro-inflammatory 12-(S)-hydroperoxyeicosatetraenoic acid (12(S)-HETE) and higher CYP2J-derived epoxyeicosatrienoic acids (EETs) levels. CYP2J-derived 5,6-, 8,9-, 11,12-, and 14,15-EETs activated macrophage-specific hemeoxygenase (HO)-1 marked with increases in F4/80(+)/Ly6C(low) and F4/80(+)/CD206(high) cells at d5 post-MI in 12/15LOX(-/-) mice. In contrast, inhibition of HO-1 led to total mortality in 12/15LOX(-/-) mice by post-MI d5. 12/15LOX(-/-) mice exhibited reduced collagen density and lower ?-smooth muscle actin (SMA) expression at d5 post-MI, indicating delayed or limited fibroblast-to-myofibroblast differentiation. In conclusion, genetic deletion of 12/15LOX reduces 12(S)-HETE and activates CYP2J-derived EETs to promote effective resolution of inflammation post-MI leading to reduced cardiac rupture, improved LV function, and better survival. |*Gene Deletion [MESH] |Animals [MESH] |Arachidonate 12-Lipoxygenase/*genetics [MESH] |Arachidonate 15-Lipoxygenase/*genetics [MESH] |Arachidonic Acid/metabolism [MESH] |Cell Polarity [MESH] |Collagen/metabolism [MESH] |Female [MESH] |Heart Failure/complications/pathology/physiopathology [MESH] |Heme Oxygenase-1/metabolism [MESH] |Inflammation/complications/*enzymology/*pathology [MESH] |Macrophages/metabolism [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Models, Biological [MESH] |Myocardial Infarction/complications/*enzymology/*pathology/physiopathology [MESH] |Myofibroblasts/metabolism/pathology [MESH] |Neutrophils/metabolism [MESH] |Phenotype [MESH] |Survival Analysis [MESH]Genetic deletion of 12/15 lipoxygenase promotes effective resolution o(epmc).pdf DeepDyve Pubget Overpricing