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10.1038/s41551-017-0084 http://scihub22266oqcxt.onion/10.1038/s41551-017-0084 C5940348!5940348!29750130     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biomed+Eng 2017 ; 1 (7): ä Nephropedia Template TP {{tp|p=29750130|t=2017. Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens |pdf=|usr=}}{{29750130}} gab.com Text Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens JO: Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=29750130 #FOAvip For the 1.7 million patients per year in the U.S. who receive a new cancer diagnosis, treatment decisions are largely made after a histopathology exam. Unfortunately, the gold standard of slide-based microscopic pathology suffers from high inter-observer variability and limited prognostic value due to sampling limitations and the inability to visualize tissue structures and molecular targets in their native 3D context. Here, we show that an open-top light-sheet microscope optimized for non-destructive slide-free pathology of clinical specimens enables the rapid imaging of intact tissues at high resolution over large 2D and 3D fields of view, with the same level of detail as traditional pathology. We demonstrate the utility of this technology for various applications: wide-area surface microscopy to triage surgical specimens (with ~200 ?m surface irregularities), rapid intraoperative assessment of tumour-margin surfaces (12.5 sec/cm2), and volumetric assessment of optically cleared core?needle biopsies (1 mm in diameter, 2 cm in length). Light-sheet microscopy can be a versatile tool for both rapid surface microscopy and deep volumetric microscopy of human specimens. Twit Text FOAVip Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens ????Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=29750130 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29750130 #FOAvip English Wikipedia <ref>{{Cite pmid|29750130}}</ref> Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens #MMPMID29750130 Glaser AK; Reder NP; Chen Y; McCarty EF; Yin C; Wei L; Wang Y; True LD; Liu JT Nat Biomed Eng 2017[Jul]; 1 (7): ä PMID29750130show ga For the 1.7 million patients per year in the U.S. who receive a new cancer diagnosis, treatment decisions are largely made after a histopathology exam. Unfortunately, the gold standard of slide-based microscopic pathology suffers from high inter-observer variability and limited prognostic value due to sampling limitations and the inability to visualize tissue structures and molecular targets in their native 3D context. Here, we show that an open-top light-sheet microscope optimized for non-destructive slide-free pathology of clinical specimens enables the rapid imaging of intact tissues at high resolution over large 2D and 3D fields of view, with the same level of detail as traditional pathology. We demonstrate the utility of this technology for various applications: wide-area surface microscopy to triage surgical specimens (with ~200 ?m surface irregularities), rapid intraoperative assessment of tumour-margin surfaces (12.5 sec/cm2), and volumetric assessment of optically cleared core?needle biopsies (1 mm in diameter, 2 cm in length). Light-sheet microscopy can be a versatile tool for both rapid surface microscopy and deep volumetric microscopy of human specimens. äLight-sheet microscopy for slide-free non-destructive pathology of lar(epmc).pdf DeepDyve Pubget Overpricing