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10.1083/jcb.201709137 http://scihub22266oqcxt.onion/10.1083/jcb.201709137 C5940306!5940306 !29511123     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29511123 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2018 ; 217 (5 ): 1739-1755 Nephropedia Template TP {{tp|p=29511123 |t=2018. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization |pdf=|usr=}}{{29511123 }} gab.com Text Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29511123 #FOAvip To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1 deficiency, IRE1 switches to perform RIDD. We examined IRE1 in XBP1-deficient B cells and discovered that IRE1 undergoes phosphorylation at S729. We generated an anti-phospho-S729 antibody to investigate such phosphorylation. Compared with pharmacological ER stress inducers or Toll-like receptor ligands, the bacterial subtilase cytotoxin has an unusual capability in causing rapid and strong phosphorylation at S729 and triggering B cells to express spliced XBP1. To assess the function of S729 in IRE1, we generated S729A knock-in mice and found S729 is critically important for lipopolysaccharide-stimulated plasmablasts to respond to additional ER stress and for antibody production in response to immunization. We further crossed mice carrying an S729A mutation or ?IRE1 (missing the kinase domain) with B cell-specific XBP1-deficient mice to trigger RIDD and discovered a critical role for S729 in regulating RIDD in B cells. Twit Text FOAVip Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29511123 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29511123 #FOAvip English Wikipedia <ref>{{Cite pmid|29511123 }}</ref> Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization #MMPMID29511123 Tang CH ; Chang S ; Paton AW ; Paton JC ; Gabrilovich DI ; Ploegh HL ; Del Valle JR ; Hu CC J Cell Biol 2018[May]; 217 (5 ): 1739-1755 PMID29511123 show ga To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1 deficiency, IRE1 switches to perform RIDD. We examined IRE1 in XBP1-deficient B cells and discovered that IRE1 undergoes phosphorylation at S729. We generated an anti-phospho-S729 antibody to investigate such phosphorylation. Compared with pharmacological ER stress inducers or Toll-like receptor ligands, the bacterial subtilase cytotoxin has an unusual capability in causing rapid and strong phosphorylation at S729 and triggering B cells to express spliced XBP1. To assess the function of S729 in IRE1, we generated S729A knock-in mice and found S729 is critically important for lipopolysaccharide-stimulated plasmablasts to respond to additional ER stress and for antibody production in response to immunization. We further crossed mice carrying an S729A mutation or ?IRE1 (missing the kinase domain) with B cell-specific XBP1-deficient mice to trigger RIDD and discovered a critical role for S729 in regulating RIDD in B cells. |*Antibody Formation [MESH] |*Immunization [MESH] |*RNA Stability [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |B-Lymphocytes/*metabolism [MESH] |Dithiothreitol/pharmacology [MESH] |Endoplasmic Reticulum Stress/drug effects [MESH] |Immunoglobulin G/blood [MESH] |Immunoglobulin M/blood [MESH] |Lipopolysaccharides [MESH] |Membrane Proteins/chemistry/*metabolism [MESH] |Mice, Inbred C57BL [MESH] |Models, Animal [MESH] |Models, Biological [MESH] |Phosphorylation [MESH] |Phosphoserine/*metabolism [MESH] |Protein Serine-Threonine Kinases/chemistry/*metabolism [MESH] |T-Lymphocytes/metabolism [MESH] |Up-Regulation/drug effects [MESH]Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody(epmc).pdf DeepDyve Pubget Overpricing