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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Alzheimers+Dis
2017 ; 59
(3
): 803-814
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Alcohol Intake and Cognitively Healthy Longevity in Community-Dwelling Adults:
The Rancho Bernardo Study
#MMPMID28671111
Richard EL
; Kritz-Silverstein D
; Laughlin GA
; Fung TT
; Barrett-Connor E
; McEvoy LK
J Alzheimers Dis
2017[]; 59
(3
): 803-814
PMID28671111
show ga
To better understand the association of alcohol intake with cognitively healthy
longevity (CHL), we explored the association between amount and frequency of
alcohol intake and CHL among 1,344 older community-dwelling adults. Alcohol
intake was assessed by questionnaire in 1984-1987. Cognitive function was
assessed in approximate four-year intervals between 1988 and 2009. Multinomial
logistic regression, adjusting for multiple lifestyle and health factors, was
used to examine the association between alcohol consumption and CHL (living to
age 85 without cognitive impairment), survival to age 85 with cognitive
impairment (MMSE score?>1.5 standard deviations below expectation for age, sex,
and education), or death before age 85. Most participants (88%) reported some
current alcohol intake; 49% reported a moderate amount of alcohol intake, and 48%
reported drinking near-daily. Relative to nondrinkers, moderate and heavy
drinkers (up to 3 drinks/day for women and for men 65 years and older, up to 4
drinks/day for men under 65 years) had significantly higher adjusted odds of
survival to age 85 without cognitive impairment (p's?0.05). Near-daily drinkers
had 2-3 fold higher adjusted odds of CHL versus living to at least age 85 with
cognitive impairment (odds ratio (OR)?=?2.06; 95% confidence interval (CI): 1.21,
3.49) or death before 85 (OR?=?3.24; 95% CI: 1.92, 5.46). Although excessive
drinking has negative health consequences, these results suggest that regular,
moderate drinking may play a role in cognitively healthy longevity.