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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Pharmacol
2017 ; 37
(ä): 142-150
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MicroRNAs in intestinal barrier function, inflammatory bowel disease and related
cancers-their effects and therapeutic potentials
#MMPMID29154194
Tili E
; Michaille JJ
; Piurowski V
; Rigot B
; Croce CM
Curr Opin Pharmacol
2017[Dec]; 37
(ä): 142-150
PMID29154194
show ga
The initiation and development or inflammatory bowel disease (IBD) and associated
colorectal cancers, have been linked to inflammation. MicroRNAs are non-coding
regulators of gene expression that have gained great attention due to their
capability to regulate the expression of a number of target transcripts. It is
now generally admitted that microRNAs are instrumental in gut pathologies, in
particular through their targeting of transcripts encoding proteins of the
intestinal barrier (IB) and their regulators. Intense research is conducted to
identify microRNAs susceptible to be used as biomarkers and to design new
therapeutic approaches based upon using synthetic microRNA mimics and inhibitors
as well as finding new drugs capable to restore or modify microRNA expression in
the context of gut pathologies.