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10.1038/s41419-018-0548-3 http://scihub22266oqcxt.onion/10.1038/s41419-018-0548-3 C5938705!5938705 !29725063     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29725063 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Death+Dis 2018 ; 9 (5 ): 517 Nephropedia Template TP {{tp|p=29725063 |t=2018. Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ |pdf=|usr=}}{{29725063 }} gab.com Text Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29725063 #FOAvip Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with the Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well as tumorigenesis. Here we first show that ACTL6A is upregulated in human gliomas and its expression is associated with glioma patient survival. ACTL6A promotes malignant behaviors of glioma cells in vitro and in orthotopic xenograft model. In co-immunoprecipitation assays, we discover that ACTL6A physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and ?-TrCP E3 ubiquitin ligase, which promotes YAP protein degradation. Moreover, effects of ACTL6A on glioma cells proliferation, migration, and invasion could be mediated by YAP/TAZ. These data indicate that ACTL6A may contribute to cancer progression by stabilizing YAP/TAZ and therefore provide a novel therapeutic target for the treatment of human gliomas. Twit Text FOAVip Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29725063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29725063 #FOAvip English Wikipedia <ref>{{Cite pmid|29725063 }}</ref> Actin like-6A promotes glioma progression through stabilization of transcriptional regulators YAP/TAZ #MMPMID29725063 Ji J ; Xu R ; Zhang X ; Han M ; Xu Y ; Wei Y ; Ding K ; Wang S ; Bin Huang ; Chen A ; Di Zhang ; Jiang Z ; Xu S ; Zhang Q ; Li W ; Ni S ; Wang J ; Li X Cell Death Dis 2018[May]; 9 (5 ): 517 PMID29725063 show ga Increased Actin-like 6A (ACTL6A) expression has been implicated in the development of diverse cancers and recently associated with the Hippo signaling pathway, which is known to regulate biological properties, including proliferation, tissue regeneration, stem cell biology, as well as tumorigenesis. Here we first show that ACTL6A is upregulated in human gliomas and its expression is associated with glioma patient survival. ACTL6A promotes malignant behaviors of glioma cells in vitro and in orthotopic xenograft model. In co-immunoprecipitation assays, we discover that ACTL6A physically associated with YAP/TAZ and furthermore disrupts the interaction between YAP and ?-TrCP E3 ubiquitin ligase, which promotes YAP protein degradation. Moreover, effects of ACTL6A on glioma cells proliferation, migration, and invasion could be mediated by YAP/TAZ. These data indicate that ACTL6A may contribute to cancer progression by stabilizing YAP/TAZ and therefore provide a novel therapeutic target for the treatment of human gliomas. |*Gene Expression Regulation, Neoplastic [MESH] |Actins/antagonists & inhibitors/*genetics/metabolism [MESH] |Adaptor Proteins, Signal Transducing/*genetics/metabolism [MESH] |Aged [MESH] |Animals [MESH] |Brain Neoplasms/*genetics/metabolism/mortality/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Chromosomal Proteins, Non-Histone/antagonists & inhibitors/*genetics/metabolism [MESH] |DNA-Binding Proteins/antagonists & inhibitors/*genetics/metabolism [MESH] |Disease Progression [MESH] |Female [MESH] |Glioblastoma/*genetics/metabolism/mortality/pathology [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/*genetics/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Phosphoproteins/*genetics/metabolism [MESH] |Protein Binding [MESH] |Protein Stability [MESH] |RNA, Small Interfering/genetics/metabolism [MESH] |Signal Transduction [MESH] |Survival Analysis [MESH] |Trans-Activators [MESH] |Transcription Factors [MESH] |Transcriptional Coactivator with PDZ-Binding Motif Proteins [MESH] |Tumor Burden [MESH] |Xenograft Model Antitumor Assays [MESH] |YAP-Signaling Proteins [MESH]Actin like-6A promotes glioma progression through stabilization of t(epmc).pdf DeepDyve Pubget Overpricing