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10.15252/emmm.201708724 http://scihub22266oqcxt.onion/10.15252/emmm.201708724 C5938619!5938619!29666146     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2018 ; 10 (5): ä Nephropedia Template TP {{tp|p=29666146|t=2018. Identification of circadian clock modulators from existing drugs |pdf=|usr=}}{{29666146}} gab.com Text Identification of circadian clock modulators from existing drugs JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29666146 #FOAvip Chronic circadian disruption due to shift work or frequent travel across time zones leads to jet?lag and an increased risk of diabetes, cardiovascular disease, and cancer. The development of new pharmaceuticals to treat circadian disorders, however, is costly and hugely time?consuming. We therefore performed a high?throughput chemical screen of existing drugs for circadian clock modulators in human U2OS cells, with the aim of repurposing known bioactive compounds. Approximately 5% of the drugs screened altered circadian period, including the period?shortening compound dehydroepiandrosterone (DHEA; also known as prasterone). DHEA is one of the most abundant circulating steroid hormones in humans and is available as a dietary supplement in the USA. Dietary administration of DHEA to mice shortened free?running circadian period and accelerated re?entrainment to advanced light?dark (LD) cycles, thereby reducing jet?lag. Our drug screen also revealed the involvement of tyrosine kinases, ABL1 and ABL2, and the BCR serine/threonine kinase in regulating circadian period. Thus, drug repurposing is a useful approach to identify new circadian clock modulators and potential therapies for circadian disorders. Twit Text FOAVip Identification of circadian clock modulators from existing drugs ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29666146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29666146 #FOAvip English Wikipedia <ref>{{Cite pmid|29666146}}</ref> Identification of circadian clock modulators from existing drugs #MMPMID29666146 Tamai TK; Nakane Y; Ota W; Kobayashi A; Ishiguro M; Kadofusa N; Ikegami K; Yagita K; Shigeyoshi Y; Sudo M; Nishiwaki?Ohkawa T; Sato A; Yoshimura T EMBO Mol Med 2018[May]; 10 (5): ä PMID29666146show ga Chronic circadian disruption due to shift work or frequent travel across time zones leads to jet?lag and an increased risk of diabetes, cardiovascular disease, and cancer. The development of new pharmaceuticals to treat circadian disorders, however, is costly and hugely time?consuming. We therefore performed a high?throughput chemical screen of existing drugs for circadian clock modulators in human U2OS cells, with the aim of repurposing known bioactive compounds. Approximately 5% of the drugs screened altered circadian period, including the period?shortening compound dehydroepiandrosterone (DHEA; also known as prasterone). DHEA is one of the most abundant circulating steroid hormones in humans and is available as a dietary supplement in the USA. Dietary administration of DHEA to mice shortened free?running circadian period and accelerated re?entrainment to advanced light?dark (LD) cycles, thereby reducing jet?lag. Our drug screen also revealed the involvement of tyrosine kinases, ABL1 and ABL2, and the BCR serine/threonine kinase in regulating circadian period. Thus, drug repurposing is a useful approach to identify new circadian clock modulators and potential therapies for circadian disorders. äIdentification of circadian clock modulators from existing drugs (epmc).pdf DeepDyve Pubget Overpricing