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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Oncol
2018 ; 8
(ä): 111
Nephropedia Template TP
gab.com Text
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English Wikipedia
Epstein-Barr Virus and Human Papillomaviruses Interactions and Their Roles in the
Initiation of Epithelial-Mesenchymal Transition and Cancer Progression
#MMPMID29765906
Cyprian FS
; Al-Farsi HF
; Vranic S
; Akhtar S
; Al Moustafa AE
Front Oncol
2018[]; 8
(ä): 111
PMID29765906
show ga
Oncoviruses are implicated in around 20% of all human cancers including both
solid and non-solid malignancies. Epstein-Barr virus (EBV) and human
papillomaviruses (HPVs) are the most common oncoviruses worldwide. Currently, it
is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and
high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or
progression of several human carcinomas, including cervical, oral, and breast.
More significantly, it has been recently pointed out that viral onco-proteins of
EBV and high-risk HPVs can be co-present and consequently cooperate to initiate
and/or amplify epithelial-mesenchymal transition (EMT), which is the hallmark of
cancer progression and metastasis. This could occur by ?-catenin, JAK/STAT/SRC,
PI3k/Akt/mTOR, and/or RAS/MEK/ERK signaling pathways, which onco-proteins of EBV
and HPVs share. This review presents the most recent advances related to EBV and
high-risk HPVs onco-proteins interactions and their roles in the progression of
human carcinomas especially oral and breast via the initiation of EMT.