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10.1038/s12276-018-0082-5 http://scihub22266oqcxt.onion/10.1038/s12276-018-0082-5 C5938019!5938019!29717105     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2018 ; 50 (5): ä Nephropedia Template TP {{tp|p=29717105|t=2018. Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging |pdf=|usr=}}{{29717105}} gab.com Text Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29717105 #FOAvip Long non-coding RNAs (lncRNAs) play key roles in various malignant tumors, including colorectal cancer (CRC). Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) is overexpressed in CRC patients, but whether it affects CRC proliferation and metastasis via regulation of heat shock protein 27 (HSP27) remains unclear. In the present study, we found that DANCR was highly expressed and correlated with proliferation and metastasis in CRC. In addition, we demonstrated that DANCR and HSP27 were both targets of microRNA-577 (miR-577) and shared the same binding site. Furthermore, we revealed that DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging. Finally, using an in vivo study, we confirmed that overexpression of DANCR promoted CRC tumor growth and liver metastasis. The present study demonstrated the function of DANCR in CRC and might provide a new target in the treatment of CRC. Twit Text FOAVip Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=29717105 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29717105 #FOAvip English Wikipedia <ref>{{Cite pmid|29717105}}</ref> Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging #MMPMID29717105 Wang Y; Lu Z; Wang N; Feng J; Zhang J; Luan L; Zhao W; Zeng X Exp Mol Med 2018[May]; 50 (5): ä PMID29717105show ga Long non-coding RNAs (lncRNAs) play key roles in various malignant tumors, including colorectal cancer (CRC). Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) is overexpressed in CRC patients, but whether it affects CRC proliferation and metastasis via regulation of heat shock protein 27 (HSP27) remains unclear. In the present study, we found that DANCR was highly expressed and correlated with proliferation and metastasis in CRC. In addition, we demonstrated that DANCR and HSP27 were both targets of microRNA-577 (miR-577) and shared the same binding site. Furthermore, we revealed that DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging. Finally, using an in vivo study, we confirmed that overexpression of DANCR promoted CRC tumor growth and liver metastasis. The present study demonstrated the function of DANCR in CRC and might provide a new target in the treatment of CRC. äLong noncoding RNA DANCR promotes colorectal cancer proliferation and (epmc).pdf DeepDyve Pubget Overpricing