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10.1371/journal.pone.0197078 http://scihub22266oqcxt.onion/10.1371/journal.pone.0197078 C5937764!5937764!29734386     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (5): ä Nephropedia Template TP {{tp|p=29734386|t=2018. Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes |pdf=|usr=}}{{29734386}} gab.com Text Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29734386 #FOAvip Background: Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear. Methods and results: We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression. No evidence was found to support the existence of BNP isoforms or other nucleotide expression apart from BNP and tdTomato. The pBNP-tdTomato-positive cells were interstitial cells and were not proliferative. Unexpectedly, both the expression and secretion of BNP increased in primary cultured neonatal cardiomyocytes after their treatment with an extract of the renal papillary tip. Intraperitoneal injection of the extract of the papillary tips reduced blood pressure from 210 mmHg to 165 mmHg, the decrease being accompanied by an increase in serum BNP and urinary cGMP production in stroke-prone spontaneously hypertensive (SHR-SP) rats. Furthermore the induction of BNP by the papillary extract from rats with heart failure due to myocardial infarction was increased in cardiomyocytes. Conclusions: These results suggested that the papillary tip express a substance that can stimulate BNP production and secretion from cardiomyocytes. Twit Text FOAVip Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29734386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29734386 #FOAvip English Wikipedia <ref>{{Cite pmid|29734386}}</ref> Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes #MMPMID29734386 Goto I; Okamoto R; Hashizume R; Suzuki N; Ito R; Yamanaka K; Saito H; Kiyonari H; Tawara I; Kageyama Y; Ogihara Y; Ali Y; Yamada N; Katayama N; Ito M PLoS One 2018[]; 13 (5): ä PMID29734386show ga Background: Brain natriuretic peptide (BNP) is an important biomarker for patients with cardiovascular diseases, including heart failure, hypertension and cardiac hypertrophy. It is also known that BNP levels are relatively higher in patients with chronic kidney disease and no heart disease; however, the mechanism remains unclear. Methods and results: We developed a BNP reporter mouse and occasionally found that this promoter was activated specifically in the papillary tip of the kidneys, and its activation was not accompanied by BNP mRNA expression. No evidence was found to support the existence of BNP isoforms or other nucleotide expression apart from BNP and tdTomato. The pBNP-tdTomato-positive cells were interstitial cells and were not proliferative. Unexpectedly, both the expression and secretion of BNP increased in primary cultured neonatal cardiomyocytes after their treatment with an extract of the renal papillary tip. Intraperitoneal injection of the extract of the papillary tips reduced blood pressure from 210 mmHg to 165 mmHg, the decrease being accompanied by an increase in serum BNP and urinary cGMP production in stroke-prone spontaneously hypertensive (SHR-SP) rats. Furthermore the induction of BNP by the papillary extract from rats with heart failure due to myocardial infarction was increased in cardiomyocytes. Conclusions: These results suggested that the papillary tip express a substance that can stimulate BNP production and secretion from cardiomyocytes. äRenal papillary tip extract stimulates BNP production and excretion fr(epmc).pdf DeepDyve Pubget Overpricing