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10.1177/1073274817729070

http://scihub22266oqcxt.onion/10.1177/1073274817729070
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C5937239!5937239!28975823
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suck abstract from ncbi


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pmid28975823      Cancer+Control 2017 ; 24 (5): ä
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  • Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue #MMPMID28975823
  • Snyder M; Gangadhara S; Brohl AS; Ludlow S; Nanjappa S
  • Cancer Control 2017[Dec]; 24 (5): ä PMID28975823show ga
  • Methylene blue is a widely used treatment for ifosfamide neurotoxicity. We present a case of severe encephalopathy complicating ifosfamide-based therapy for recurrent retroperitoneal leiomyosarcoma. After treatment with methylene blue, the patient experienced clinical decompensation and was diagnosed with serotonin syndrome based on a constellation of clinical findings. Withdrawal of methylene blue and other serotonergic medications led to clinical stabilization and ultimately neurological recovery. Our case highlights the challenge of diagnosing serotonin syndrome in the face of preexisting ifosfamide neurotoxicity, as there is significant clinical overlap between these 2 syndromes. Practitioners must remain vigilant of this potential life-threatening complication in this vulnerable population.
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