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10.4081/ni.2018.7516 http://scihub22266oqcxt.onion/10.4081/ni.2018.7516 C5937219!5937219!29844889     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neurol+Int 2018 ; 10 (1): ä Nephropedia Template TP {{tp|p=29844889|t=2018. Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and treatments |pdf=|usr=}}{{29844889}} gab.com Text Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and treatments JO: Neurol Int http://www.kidney.de/pget.php?&tw=1&pmid=29844889 #FOAvip Pantothenate Kinase-Associated Neurodegeneration (PKAN) is an autosomal recessive disorder characterized by a mutation in the PANK2 gene. The clinical presentation may range from only speech disorder to severe generalized dystonia, spasticity, Visual loss, dysphagia and dementia. The hallmark of this disease is eyes of the tiger sign in the medial aspect of bilateral globus pallidus on T2-weighted MRI that is a hyperintense lesion surrounded by hypointensity. Common treatments for PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal baclofen, Iron chelation drugs and surgical procedures such as ablative pallidotomy or thalamotomy, Deep brain stimulation. There are many controversies about the pathogenesis and treatment of this disease, and in recent years interesting studies have been done on PKAN disease and other similar diseases. This review summarizes the clinical presentation, etiology, imaging modalities and treatment. Twit Text FOAVip Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and treatments ????Neurol Int http://www.kidney.de/pget.php?&tw=1&pmid=29844889 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29844889 #FOAvip English Wikipedia <ref>{{Cite pmid|29844889}}</ref> Pantothenate kinase-associated neurodegeneration: Clinical aspects, diagnosis and treatments #MMPMID29844889 Razmeh S; Habibi AH; Orooji M; Alizadeh E; Moradiankokhdan K; Razmeh B Neurol Int 2018[Mar]; 10 (1): ä PMID29844889show ga Pantothenate Kinase-Associated Neurodegeneration (PKAN) is an autosomal recessive disorder characterized by a mutation in the PANK2 gene. The clinical presentation may range from only speech disorder to severe generalized dystonia, spasticity, Visual loss, dysphagia and dementia. The hallmark of this disease is eyes of the tiger sign in the medial aspect of bilateral globus pallidus on T2-weighted MRI that is a hyperintense lesion surrounded by hypointensity. Common treatments for PKAN disease include anticholinergics, botulinum toxin, Oral and Intrathecal baclofen, Iron chelation drugs and surgical procedures such as ablative pallidotomy or thalamotomy, Deep brain stimulation. There are many controversies about the pathogenesis and treatment of this disease, and in recent years interesting studies have been done on PKAN disease and other similar diseases. This review summarizes the clinical presentation, etiology, imaging modalities and treatment. äPantothenate kinase-associated neurodegeneration: Clinical aspects, di(epmc).pdf DeepDyve Pubget Overpricing