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10.1177/1753465817750075

http://scihub22266oqcxt.onion/10.1177/1753465817750075
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C5937156!5937156!29385894
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suck abstract from ncbi

pmid29385894      Ther+Adv+Respir+Dis 2018 ; 12 (ä): ä
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  • Role of immune-checkpoint inhibitors in lung cancer #MMPMID29385894
  • Jain P; Jain C; Velcheti V
  • Ther Adv Respir Dis 2018[Jan]; 12 (ä): ä PMID29385894show ga
  • Immune checkpoint inhibitors, mainly drugs targeting the programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) and cytotoxic T-lymphocyte antigen 4 (CTLA4) pathways, represent a remarkable advance in lung cancer treatment. Immune checkpoint inhibitors targeting PD-1 and PD-L1 are approved for the treatment of patients with non-small-cell lung cancer, with impressive clinical activity and durable responses in some patients. This review will summarize the mechanism of action of these drugs, the clinical development of these agents and the current role of these agents in the management of patients with lung cancer. In addition, the review will discuss the role of predictive biomarkers for optimal patient selection for immunotherapy and management of autoimmune side effects of these agents.
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