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10.1186/s12883-018-1067-7

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suck abstract from ncbi


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pmid29734949
      BMC+Neurol 2018 ; 18 (1 ): 62
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  • A case of hyperparathyroidism-associated parkinsonism successfully treated with cinacalcet hydrochloride, a calcimimetic #MMPMID29734949
  • Ohya Y ; Osaki M ; Sakai S ; Kimura S ; Yasuda C ; Ago T ; Kitazono T ; Arakawa S
  • BMC Neurol 2018[May]; 18 (1 ): 62 PMID29734949 show ga
  • BACKGROUND: Some metabolic disorders, including abnormal calcium metabolism, can develop and worsen parkinsonism. However, whether hyperparathyroidism can cause parkinsonism remains controversial. CASE PRESENTATION: An 83-year-old woman with a history of right thalamic hemorrhage and drug-induced parkinsonism, was admitted due to worsening of parkinsonian symptoms including mask-like face, bradykinesia, freezing of gait, and rigidity. She had been diagnosed with autoimmune hepatitis and was being treated with prednisolone. Examinations revealed hypercalcemia (14.3 mg/dL) with an increased level of intact parathyroid hormone (iPTH) (361 pg/mL). Her symptoms were resistant to some additional anti-parkinsonian drugs; however, cinacalcet hydrochloride, a calcimimetic for the treatment of secondary hyperparathyroidism, normalized levels of serum calcium and iPTH, and remarkably improved her symptoms. CONCLUSIONS: In the present case, we speculate that hypercalcemia probably due to secondary hyperparathyroidism that had developed during steroid therapy deteriorated the parkinsonism.
  • |Aged, 80 and over [MESH]
  • |Calcimimetic Agents/*therapeutic use [MESH]
  • |Cinacalcet/*therapeutic use [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypercalcemia/drug therapy/etiology [MESH]
  • |Hyperparathyroidism, Secondary/*complications/*drug therapy [MESH]
  • |Middle Aged [MESH]


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