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2018 ; 18
(1
): 62
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English Wikipedia
A case of hyperparathyroidism-associated parkinsonism successfully treated with
cinacalcet hydrochloride, a calcimimetic
#MMPMID29734949
Ohya Y
; Osaki M
; Sakai S
; Kimura S
; Yasuda C
; Ago T
; Kitazono T
; Arakawa S
BMC Neurol
2018[May]; 18
(1
): 62
PMID29734949
show ga
BACKGROUND: Some metabolic disorders, including abnormal calcium metabolism, can
develop and worsen parkinsonism. However, whether hyperparathyroidism can cause
parkinsonism remains controversial. CASE PRESENTATION: An 83-year-old woman with
a history of right thalamic hemorrhage and drug-induced parkinsonism, was
admitted due to worsening of parkinsonian symptoms including mask-like face,
bradykinesia, freezing of gait, and rigidity. She had been diagnosed with
autoimmune hepatitis and was being treated with prednisolone. Examinations
revealed hypercalcemia (14.3 mg/dL) with an increased level of intact parathyroid
hormone (iPTH) (361 pg/mL). Her symptoms were resistant to some additional
anti-parkinsonian drugs; however, cinacalcet hydrochloride, a calcimimetic for
the treatment of secondary hyperparathyroidism, normalized levels of serum
calcium and iPTH, and remarkably improved her symptoms. CONCLUSIONS: In the
present case, we speculate that hypercalcemia probably due to secondary
hyperparathyroidism that had developed during steroid therapy deteriorated the
parkinsonism.