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10.3389/fimmu.2018.00901 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00901 C5936983!5936983!29760707     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29760707|t=2018. The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis |pdf=|usr=}}{{29760707}} gab.com Text The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29760707 #FOAvip Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune cells, but also actively start to phagocytose and kill pathogens. In the case of sepsis, this tightly regulated host defense mechanism can become uncontrolled and hyperactive resulting in severe organ damage. Currently, no effective therapy is available to fight sepsis; therefore, novel treatment targets that could prevent excessive inflammatory responses are warranted. Src Family tyrosine Kinases (SFK), a group of tyrosine kinases, have been shown to play a major role in regulating immune cell recruitment and host defense. Leukocytes with SFK depletion display severe spreading and migration defects along with reduced cytokine production. Thus, we investigated the effects of dasatinib, a tyrosine kinase inhibitor, with a strong inhibitory capacity on SFKs during sterile inflammation and polymicrobial sepsis in mice. We found that dasatinib-treated mice displayed diminished leukocyte adhesion and extravasation in tumor necrosis factor-?-stimulated cremaster muscle venules in vivo. In polymicrobial sepsis, sepsis severity, organ damage, and clinical outcome improved in a dose-dependent fashion pointing toward an optimal therapeutic window for dasatinib dosage during polymicrobial sepsis. Dasatinib treatment may, therefore, provide a balanced immune response by preventing an overshooting inflammatory reaction on the one side and bacterial overgrowth on the other side. Twit Text FOAVip The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29760707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29760707 #FOAvip English Wikipedia <ref>{{Cite pmid|29760707}}</ref> The Yin and Yang of Tyrosine Kinase Inhibition During Experimental Polymicrobial Sepsis #MMPMID29760707 Gonçalves-de-Albuquerque CF; Rohwedder I; Silva AR; Ferreira AS; Kurz ARM; Cougoule C; Klapproth S; Eggersmann T; Silva JD; de Oliveira GP; Capelozzi VL; Schlesinger GG; Costa ER; Estrela Marins Rde CE; Mócsai A; Maridonneau-Parini I; Walzog B; Macedo Rocco PR; Sperandio M; de Castro-Faria-Neto HC Front Immunol 2018[]; 9 (ä): ä PMID29760707show ga Neutrophils are the first cells of our immune system to arrive at the site of inflammation. They release cytokines, e.g., chemokines, to attract further immune cells, but also actively start to phagocytose and kill pathogens. In the case of sepsis, this tightly regulated host defense mechanism can become uncontrolled and hyperactive resulting in severe organ damage. Currently, no effective therapy is available to fight sepsis; therefore, novel treatment targets that could prevent excessive inflammatory responses are warranted. Src Family tyrosine Kinases (SFK), a group of tyrosine kinases, have been shown to play a major role in regulating immune cell recruitment and host defense. Leukocytes with SFK depletion display severe spreading and migration defects along with reduced cytokine production. Thus, we investigated the effects of dasatinib, a tyrosine kinase inhibitor, with a strong inhibitory capacity on SFKs during sterile inflammation and polymicrobial sepsis in mice. We found that dasatinib-treated mice displayed diminished leukocyte adhesion and extravasation in tumor necrosis factor-?-stimulated cremaster muscle venules in vivo. In polymicrobial sepsis, sepsis severity, organ damage, and clinical outcome improved in a dose-dependent fashion pointing toward an optimal therapeutic window for dasatinib dosage during polymicrobial sepsis. Dasatinib treatment may, therefore, provide a balanced immune response by preventing an overshooting inflammatory reaction on the one side and bacterial overgrowth on the other side. äThe Yin and Yang of Tyrosine Kinase Inhibition During Experimental Pol(epmc).pdf DeepDyve Pubget Overpricing