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2016 ; 3
(ä): 102-110
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The role of corruption and unethical behaviour in precluding the placement of
industry sponsored clinical trials in sub-Saharan Africa: Stakeholder views
#MMPMID29736462
Egharevba E
; Atkinson J
Contemp Clin Trials Commun
2016[Aug]; 3
(ä): 102-110
PMID29736462
show ga
Clinical trials still represent the gold standard in testing the safety and
efficacy of new and existing treatments. However, developing regions including
sub-Saharan Africa remain underrepresented in pharmaceutical industry sponsored
trials for a number of reasons including fear of corruption and unethical
behaviour. This fear exists both on the part of pharmaceutical companies, and
investigators carrying out research in the region. The objective of this research
was to understand the ethical considerations associated with the conduct of
pharmaceutical industry sponsored clinical trials in sub-Saharan Africa.
Corruption was identified as a significant issue by a number of stakeholders who
participated in semi-structured interviews and completed questionnaires.
Additionally, fear of being perceived as corrupt or unethical even when
conducting ethically sound research was raised as a concern. Thus corruption,
whether actual or perceived, is one of a number of issues which have precluded
the placement of a greater number of pharmaceutical sponsored clinical trials in
this region. More discussion around corruption with all relevant stakeholders is
required in order for progress to be made and to enable greater involvement of
sub-Saharan African countries in the conduct of industry sponsored clinical
trials.