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10.1016/j.conctc.2015.11.001

http://scihub22266oqcxt.onion/10.1016/j.conctc.2015.11.001
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C5935826!5935826!29736438
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suck abstract from ncbi


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pmid29736438      Contemp+Clin+Trials+Commun 2015 ; 1 (ä): 39-41
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  • Treating Clostridium difficile infections: Should fecal microbiota transplantation be reclassified from investigational drug to human tissue?? #MMPMID29736438
  • Stuntz M; des Vignes F
  • Contemp Clin Trials Commun 2015[Oct]; 1 (ä): 39-41 PMID29736438show ga
  • Fecal microbiota transplantation (FMT) has emerged as a highly effective treatment for Clostridium difficile infection (CDI), the most frequent cause of hospital-acquired infectious diarrhea in developed countries and the cause of nearly 30,000 annual deaths in the US. FMT is proving to be more effective at treating CDI than traditional antibacterial therapy, and reduces the exposure of valuable antibiotics to potential resistance. A systematic review to assess the efficacy of FMT for CDI treatment showed that across all studies for recurrent CDI, symptom resolution was observed in 85% of patients. The United States Food and Drug Administration currently classifies FMT as an investigational drug, which imparts overly restrictive regulations that are impossible to apply to FMT in the same manner as conventional drugs. Reclassification of FMT to a human cell, tissue, and cellular and tissue-based product could potentially expand access to this important treatment while maintaining rigorous safety standards.
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