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10.15252/embr.201745054 http://scihub22266oqcxt.onion/10.15252/embr.201745054 C5934775!5934775!29643120     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2018 ; 19 (5): ä Nephropedia Template TP {{tp|p=29643120|t=2018. EphrinB2/EphB4 signaling regulates non?sprouting angiogenesis by VEGF |pdf=|usr=}}{{29643120}} gab.com Text EphrinB2/EphB4 signaling regulates non sprouting angiogenesis by VEGF JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643120 #FOAvip Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best?understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unknown. Here, we identify ephrinB2/EphB4 signaling as a key regulator of intussusceptive angiogenesis and its outcome under therapeutically relevant conditions. EphB4 signaling fine?tunes the degree of endothelial proliferation induced by specific VEGF doses during the initial stage of circumferential enlargement of vessels, thereby limiting their size and subsequently enabling successful splitting into normal capillary networks. Mechanistically, EphB4 neither inhibits VEGF?R2 activation by VEGF nor its internalization, but it modulates VEGF?R2 downstream signaling through phospho?ERK1/2. In vivo inhibitor experiments show that ERK1/2 activity is required for EphB4 regulation of VEGF?induced intussusceptive angiogenesis. Lastly, after clinically relevant VEGF gene delivery with adenoviral vectors, pharmacological stimulation of EphB4 normalizes dysfunctional vascular growth in both normoxic and ischemic muscle. These results identify EphB4 as a druggable target to modulate the outcome of VEGF gene delivery and support further investigation of its therapeutic potential. Twit Text FOAVip EphrinB2/EphB4 signaling regulates non sprouting angiogenesis by VEGF ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=29643120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29643120 #FOAvip English Wikipedia <ref>{{Cite pmid|29643120}}</ref> EphrinB2/EphB4 signaling regulates non?sprouting angiogenesis by VEGF #MMPMID29643120 Groppa E; Brkic S; Uccelli A; Wirth G; Korpisalo?Pirinen P; Filippova M; Dasen B; Sacchi V; Muraro MG; Trani M; Reginato S; Gianni?Barrera R; Ylä?Herttuala S; Banfi A EMBO Rep 2018[May]; 19 (5): ä PMID29643120show ga Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best?understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unknown. Here, we identify ephrinB2/EphB4 signaling as a key regulator of intussusceptive angiogenesis and its outcome under therapeutically relevant conditions. EphB4 signaling fine?tunes the degree of endothelial proliferation induced by specific VEGF doses during the initial stage of circumferential enlargement of vessels, thereby limiting their size and subsequently enabling successful splitting into normal capillary networks. Mechanistically, EphB4 neither inhibits VEGF?R2 activation by VEGF nor its internalization, but it modulates VEGF?R2 downstream signaling through phospho?ERK1/2. In vivo inhibitor experiments show that ERK1/2 activity is required for EphB4 regulation of VEGF?induced intussusceptive angiogenesis. Lastly, after clinically relevant VEGF gene delivery with adenoviral vectors, pharmacological stimulation of EphB4 normalizes dysfunctional vascular growth in both normoxic and ischemic muscle. These results identify EphB4 as a druggable target to modulate the outcome of VEGF gene delivery and support further investigation of its therapeutic potential. äEphrinB2/EphB4 signaling regulates non?sprouting angiogenesis by VEGF (epmc).pdf DeepDyve Pubget Overpricing