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10.15252/embr.201744722 http://scihub22266oqcxt.onion/10.15252/embr.201744722 C5934773!5934773!29592859     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2018 ; 19 (5): ä Nephropedia Template TP {{tp|p=29592859|t=2018. Stress granules counteract senescence by sequestration of PAI?1 |pdf=|usr=}}{{29592859}} gab.com Text Stress granules counteract senescence by sequestration of PAI 1 JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=29592859 #FOAvip Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the progression of senescence and the behavior of senescent cells. We show that constitutive exposure to stress induces the formation of stress granules (SGs) in proliferative and presenescent cells, but not in fully senescent cells. Stress granule assembly alone is sufficient to decrease the number of senescent cells without affecting the expression of bona fide senescence markers. SG?mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor?1 (PAI?1), a known promoter of senescence, to these entities. PAI?1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non?senescent state. Together, our data indicate that SGs may be targets of intervention to modulate senescence in order to impair or prevent its deleterious effects. Twit Text FOAVip Stress granules counteract senescence by sequestration of PAI 1 ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=29592859 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29592859 #FOAvip English Wikipedia <ref>{{Cite pmid|29592859}}</ref> Stress granules counteract senescence by sequestration of PAI?1 #MMPMID29592859 Omer A; Patel D; Lian XJ; Sadek J; Di Marco S; Pause A; Gorospe M; Gallouzi IE EMBO Rep 2018[May]; 19 (5): ä PMID29592859show ga Cellular senescence is a physiological response by which an organism halts the proliferation of potentially harmful and damaged cells. However, the accumulation of senescent cells over time can become deleterious leading to diseases and physiological decline. Our data reveal a novel interplay between senescence and the stress response that affects both the progression of senescence and the behavior of senescent cells. We show that constitutive exposure to stress induces the formation of stress granules (SGs) in proliferative and presenescent cells, but not in fully senescent cells. Stress granule assembly alone is sufficient to decrease the number of senescent cells without affecting the expression of bona fide senescence markers. SG?mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor?1 (PAI?1), a known promoter of senescence, to these entities. PAI?1 localization to SGs increases the translocation of cyclin D1 to the nucleus, promotes RB phosphorylation, and maintains a proliferative, non?senescent state. Together, our data indicate that SGs may be targets of intervention to modulate senescence in order to impair or prevent its deleterious effects. äStress granules counteract senescence by sequestration of PAI?1 (epmc).pdf DeepDyve Pubget Overpricing