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10.1093/nar/gky186 http://scihub22266oqcxt.onion/10.1093/nar/gky186 C5934658!5934658!29547894     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nucleic+Acids+Res 2018 ; 46 (8): 4054-71 Nephropedia Template TP {{tp|p=29547894|t=2018. A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing |pdf=|usr=}}{{29547894}} gab.com Text A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing JO: Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=29547894 #FOAvip STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce type I interferon (IFN) production. Particularly, STING is activated by 2?3?-cGAMP, a cyclic dinucleotide containing mixed phosphodiester linkages and produced by cytoplasmic DNA sensor cGAS. Here, we reported on a novel transcript isoform of STING designated STING-? that dominantly inhibits innate nucleic acid sensing. STING-? without transmembrane domains was widely expressed at low levels in various human tissues and viral induction of STING-? correlated inversely with IFN-? production. The expression of STING-? declined in patients with lupus, in which type I IFNs are commonly overproduced. STING-? suppressed the induction of IFNs, IFN-stimulated genes and other cytokines by various immunostimulatory agents including cyclic dinucleotides, DNA, RNA and viruses, whereas depletion of STING-? showed the opposite effect. STING-? interacted with STING-? and antagonized its antiviral function. STING-? also interacted with TBK1 and prevented it from binding with STING-?, TRIF or other transducers. In addition, STING-? bound to 2?3?-cGAMP and impeded its binding with and activation of STING-?, leading to suppression of IFN-? production. Taken together, STING-? sequesters 2?3?-cGAMP second messenger and other transducer molecules to inhibit innate nucleic acid sensing dominantly. Twit Text FOAVip A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing ????Nucleic Acids Res http://www.kidney.de/pget.php?&tw=1&pmid=29547894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29547894 #FOAvip English Wikipedia <ref>{{Cite pmid|29547894}}</ref> A novel transcript isoform of STING that sequesters cGAMP and dominantly inhibits innate nucleic acid sensing #MMPMID29547894 Wang PH; Fung SY; Gao WW; Deng JJ; Cheng Y; Chaudhary V; Yuen KS; Ho TH; Chan CP; Zhang Y; Kok KH; Yang W; Chan CP; Jin DY Nucleic Acids Res 2018[May]; 46 (8): 4054-71 PMID29547894show ga STING is a core adaptor in innate nucleic acid sensing in mammalian cells, on which different sensing pathways converge to induce type I interferon (IFN) production. Particularly, STING is activated by 2?3?-cGAMP, a cyclic dinucleotide containing mixed phosphodiester linkages and produced by cytoplasmic DNA sensor cGAS. Here, we reported on a novel transcript isoform of STING designated STING-? that dominantly inhibits innate nucleic acid sensing. STING-? without transmembrane domains was widely expressed at low levels in various human tissues and viral induction of STING-? correlated inversely with IFN-? production. The expression of STING-? declined in patients with lupus, in which type I IFNs are commonly overproduced. STING-? suppressed the induction of IFNs, IFN-stimulated genes and other cytokines by various immunostimulatory agents including cyclic dinucleotides, DNA, RNA and viruses, whereas depletion of STING-? showed the opposite effect. STING-? interacted with STING-? and antagonized its antiviral function. STING-? also interacted with TBK1 and prevented it from binding with STING-?, TRIF or other transducers. In addition, STING-? bound to 2?3?-cGAMP and impeded its binding with and activation of STING-?, leading to suppression of IFN-? production. Taken together, STING-? sequesters 2?3?-cGAMP second messenger and other transducer molecules to inhibit innate nucleic acid sensing dominantly. äA novel transcript isoform of STING that sequesters cGAMP and dominant(epmc).pdf DeepDyve Pubget Overpricing