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http://scihub22266oqcxt.onion/ C5934567!5934567!29736201     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transl+Res 2018 ; 10 (4): 1071-84 Nephropedia Template TP {{tp|p=29736201|t=2018. Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice |pdf=|usr=}}{{29736201}} gab.com Text Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice JO: Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=29736201 #FOAvip Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). Evidence has suggested that niclosamide ethanolamine salt (NEN) could improve diabetic symptoms in mice of type 2 diabetes (T2D). However, its role in T1D and DKD has not been studied to date. Here we report that NEN could protect against diabetes in streptozotocin (STZ) induced T1D mice. It increased serum insulin levels, corrected the unbalanced ratio of ?-cells to ?-cells, and induced islet morphologic changes under diabetic conditions. In addition, NEN could impede the progression of DKD in T1D. Specifically, it reduced urinary albumin levels, NAG, NGAL and TGF-?1 excretion, ameliorated renal hypertrophy, alleviated podocyte dysfunction, and suppressed the renal cortical activation of mTOR/4E-BP1 signaling pathway. Moreover, it is hepatoprotective and does not exhibit heart toxicity. Therefore, these findings open up a completely novel therapy for diabetes and DKD. Twit Text FOAVip Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice ????Am J Transl Res http://www.kidney.de/pget.php?&tw=1&pmid=29736201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29736201 #FOAvip English Wikipedia <ref>{{Cite pmid|29736201}}</ref> Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice #MMPMID29736201 Han P; Shao M; Guo L; Wang W; Song G; Yu X; Zhang C; Ge N; Yi T; Li S; Du H; Sun H Am J Transl Res 2018[]; 10 (4): 1071-84 PMID29736201show ga Diabetes and its renal complications are major medical challenges worldwide. There are no effective drugs currently available for treating diabetes and diabetic kidney disease (DKD), especially in type 1 diabetes (T1D). Evidence has suggested that niclosamide ethanolamine salt (NEN) could improve diabetic symptoms in mice of type 2 diabetes (T2D). However, its role in T1D and DKD has not been studied to date. Here we report that NEN could protect against diabetes in streptozotocin (STZ) induced T1D mice. It increased serum insulin levels, corrected the unbalanced ratio of ?-cells to ?-cells, and induced islet morphologic changes under diabetic conditions. In addition, NEN could impede the progression of DKD in T1D. Specifically, it reduced urinary albumin levels, NAG, NGAL and TGF-?1 excretion, ameliorated renal hypertrophy, alleviated podocyte dysfunction, and suppressed the renal cortical activation of mTOR/4E-BP1 signaling pathway. Moreover, it is hepatoprotective and does not exhibit heart toxicity. Therefore, these findings open up a completely novel therapy for diabetes and DKD. äNiclosamide ethanolamine improves diabetes and diabetic kidney disease(epmc).pdf DeepDyve Pubget Overpricing