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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP
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Molecular Determinants of Target Cell Recognition by Human ?? T Cells #MMPMID29755480
Simões AE; Di Lorenzo B; Silva-Santos B
Front Immunol 2018[]; 9 (ä): ä PMID29755480show ga
The unique capabilities of gamma-delta (??) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of ?? T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain. Here, we review the accumulated knowledge on the diverse mechanisms of target cell recognition by ?? T cells, focusing on human ?? T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases.