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2018 ; 8
(1
): 6968
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White donor, younger donor and double lung transplant are associated with better
survival in sarcoidosis patients
#MMPMID29725035
Salamo O
; Roghaee S
; Schweitzer MD
; Mantero A
; Shafazand S
; Campos M
; Mirsaeidi M
Sci Rep
2018[May]; 8
(1
): 6968
PMID29725035
show ga
Sarcoidosis commonly affects the lung. Lung transplantation (LT) is required when
there is a severe and refractory involvement. We compared post-transplant
survival rates of sarcoidosis patients with chronic obstructive pulmonary disease
(COPD) and idiopathic pulmonary fibrosis (IPF). We also explored whether the race
and age of the donor, and double lung transplant have any effect on the survival
in the post transplant setting. We analyzed 9,727 adult patients with
sarcoidosis, COPD, and IPF who underwent LT worldwide between 2005-2015 based on
United Network for Organ Sharing (UNOS) database. Survival rates were compared
with Kaplan-Meier, and risk factors were investigated by Cox-regression analysis.
469 (5%) were transplanted because of sarcoidosis, 3,688 (38%) for COPD and 5,570
(57%) for IPF. Unadjusted survival analysis showed a better post-transplant
survival rate for patients with sarcoidosis (p?0.001, Log-rank test). In
Cox-regression analysis, double lung transplant and white race of the lung donor
showed to have a significant survival advantage. Since double lung transplant,
those who are younger and have lower Lung Allocation Score (LAS) at the time of
transplant have a survival advantage, we suggest double lung transplant as the
procedure of choice, especially in younger sarcoidosis subjects and with lower
LAS scores.