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10.1146/annurev-pathol-052016-100127

http://scihub22266oqcxt.onion/10.1146/annurev-pathol-052016-100127
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C5933931!5933931!27959635
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suck abstract from ncbi

pmid27959635      Annu+Rev+Pathol 2017 ; 12 (ä): 245-75
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  • The Varied Roles of Notch in Cancer #MMPMID27959635
  • Aster JC; Pear WS; Blacklow SC
  • Annu Rev Pathol 2017[Jan]; 12 (ä): 245-75 PMID27959635show ga
  • Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.
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