Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.pone.0196897 http://scihub22266oqcxt.onion/10.1371/journal.pone.0196897 C5933780!5933780!29723264     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (5): ä Nephropedia Template TP {{tp|p=29723264|t=2018. Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-?B pathway |pdf=|usr=}}{{29723264}} gab.com Text Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF- B pathway JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29723264 #FOAvip Dexmedetomidine (DEX) is known to provide neuroprotective effect in the central nervous system. However, the detailed mechanism remains far more elusive. This study was designed to investigate the relevant mechanisms of DEX's neuroprotective effect. Sprague?Dawley (SD) rats were injected with dexmedetomidine and/or Lipopolysaccharide (LPS) intraperitoneally, and inflammatory cytokines in serum and in the hippocampus were measured by enzyme linked immunosorbent assay (ELISA). NF-?B in the brain tissue extracts was analyzed with western-blot. Then, we investigated whether NF-?B inhibitor prevents the elevation of inflammatory cytokines in rats injected with LPS. Our results indicated that compared with the control group, the rats exposed to LPS showed significant cognitive dysfunction. When compared to controls, the levels of TNF-? and IL-6 in the serum and hippocampus homogenate were increased in rats treated with LPS. DEX pretreatment inhibited the rats' TNF-?, IL-6 and NF-?B levels induced by LPS. In response to LPS, PDTC pretreatment restrains the production of proinflammatory cytokines (TNF-? and IL-6). Rats treated with PDTC and DEX alongside LPS exhibited less TNF-? and IL-6 than the LPS treated group. In combination, PDTC and DEX showed addictive effects. Our data suggest that DEX exerts a neuroprotective effect through NF-?B in part after LPS-induced cognitive dysfunction. Twit Text FOAVip Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF- B pathway ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29723264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29723264 #FOAvip English Wikipedia <ref>{{Cite pmid|29723264}}</ref> Dexmedetomidine inhibits inflammatory reaction in the hippocampus of septic rats by suppressing NF-?B pathway #MMPMID29723264 Zhang X; Yan F; Feng J; Qian H; Cheng Z; Yang Q; Wu Y; Zhao Z; Li A; Xiao H PLoS One 2018[]; 13 (5): ä PMID29723264show ga Dexmedetomidine (DEX) is known to provide neuroprotective effect in the central nervous system. However, the detailed mechanism remains far more elusive. This study was designed to investigate the relevant mechanisms of DEX's neuroprotective effect. Sprague?Dawley (SD) rats were injected with dexmedetomidine and/or Lipopolysaccharide (LPS) intraperitoneally, and inflammatory cytokines in serum and in the hippocampus were measured by enzyme linked immunosorbent assay (ELISA). NF-?B in the brain tissue extracts was analyzed with western-blot. Then, we investigated whether NF-?B inhibitor prevents the elevation of inflammatory cytokines in rats injected with LPS. Our results indicated that compared with the control group, the rats exposed to LPS showed significant cognitive dysfunction. When compared to controls, the levels of TNF-? and IL-6 in the serum and hippocampus homogenate were increased in rats treated with LPS. DEX pretreatment inhibited the rats' TNF-?, IL-6 and NF-?B levels induced by LPS. In response to LPS, PDTC pretreatment restrains the production of proinflammatory cytokines (TNF-? and IL-6). Rats treated with PDTC and DEX alongside LPS exhibited less TNF-? and IL-6 than the LPS treated group. In combination, PDTC and DEX showed addictive effects. Our data suggest that DEX exerts a neuroprotective effect through NF-?B in part after LPS-induced cognitive dysfunction. äDexmedetomidine inhibits inflammatory reaction in the hippocampus of s(epmc).pdf DeepDyve Pubget Overpricing