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10.5414/CNCS109321

http://scihub22266oqcxt.onion/10.5414/CNCS109321
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C5933309!5933309!29845002
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suck abstract from ncbi


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pmid29845002      Clin+Nephrol+Case+Stud 2018 ; 6 (ä): 4-10
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  • Rituximab for retroperitoneal fibrosis due to IgG4-related disease: A case report and literature review #MMPMID29845002
  • Almeqdadi M; Al-Dulaimi M; Perepletchikov A; Tomera K; Jaber BL
  • Clin Nephrol Case Stud 2018[]; 6 (ä): 4-10 PMID29845002show ga
  • Retroperitoneal fibrosis (RPF) is a progressive fibroinflammatory disease that can be complicated by urinary obstruction. RPF can be the only manifestation of IgG4-related disease (IgG4-RD). Treatment of IgG4-related RPF is challenging and mostly consists of long-term glucocorticoids leading to significant side effects and treatment intolerance. Recent exploration of the role of rituximab as a B-cell depleting therapy in the treatment of IgG4-RD provides therapeutic potential as a well-tolerated alternative to glucocorticoids. We present a case of IgG4-related RPF for which rituximab was instituted as a steroid-sparing treatment strategy. Following 4 doses, kidney function partially recovered, and the disease went into remission. We discuss the potential merit of rituximab for the treatment of patients with IgG4-related RPF.
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