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10.3389/fimmu.2018.00941

http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00941
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suck abstract from ncbi


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pmid29755481
      Front+Immunol 2018 ; 9 (ä): 941
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  • "Phage Transplantation in Allotransplantation": Possible Treatment in Graft-Versus-Host Disease? #MMPMID29755481
  • Górski A ; Jo?czyk-Matysiak E ; Mi?dzybrodzki R ; Weber-D?browska B ; Borysowski J
  • Front Immunol 2018[]; 9 (ä): 941 PMID29755481 show ga
  • Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD.
  • |*Phage Therapy/methods [MESH]
  • |Animals [MESH]
  • |Bacteriophages/*physiology [MESH]
  • |Graft vs Host Disease/diagnosis/*etiology/*therapy [MESH]
  • |Hematopoietic Stem Cell Transplantation/*adverse effects [MESH]
  • |Humans [MESH]
  • |Immunomodulation [MESH]
  • |Microbiota [MESH]
  • |Neutrophils/immunology/metabolism [MESH]
  • |Transplantation, Homologous [MESH]


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