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10.5483/BMBRep.2018.51.4.033 http://scihub22266oqcxt.onion/10.5483/BMBRep.2018.51.4.033 C5933212!5933212!29429451     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMB+Rep 2018 ; 51 (4): 174-81 Nephropedia Template TP {{tp|p=29429451|t=2018. Emerging role of RUNX3 in the regulation of tumor microenvironment |pdf=|usr=}}{{29429451}} gab.com Text Emerging role of RUNX3 in the regulation of tumor microenvironment JO: BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=29429451 #FOAvip A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy. Twit Text FOAVip Emerging role of RUNX3 in the regulation of tumor microenvironment ????BMB Rep http://www.kidney.de/pget.php?&tw=1&pmid=29429451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29429451 #FOAvip English Wikipedia <ref>{{Cite pmid|29429451}}</ref> Emerging role of RUNX3 in the regulation of tumor microenvironment #MMPMID29429451 Manandhar S; Lee YM BMB Rep 2018[Apr]; 51 (4): 174-81 PMID29429451show ga A number of genes have been therapeutically targeted to relieve cancer, but cancer relapse is still a growing issue. The concept that the surrounding tumor environment is critical for the progression of cancer may foster an answer to the issue of cancer malignancy. Runt domain transcription factors (RUNX1, 2, and 3) are evolutionarily conserved and have been intensively studied for their roles in normal development and pathological conditions. During tumor growth, a hypoxic microenvironment and infiltration of the tumor by immune cells are common phenomena. In this review, we briefly introduce the consequences of hypoxia and immune cell infiltration into the tumor microenvironment with a focus on RUNX3 as a critical regulator. Furthermore, based on our current knowledge of the functional role of RUNX3 in hypoxia and immune cell maintenance, a probable therapeutic intervention is suggested for the effective management of tumor growth and malignancy. äEmerging role of RUNX3 in the regulation of tumor microenvironment (epmc).pdf DeepDyve Pubget Overpricing