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10.3389/fimmu.2018.00853 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00853 C5932347!5932347!29755463     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29755463|t=2018. The Role of Optineurin in Antiviral Type I Interferon Production |pdf=|usr=}}{{29755463}} gab.com Text The Role of Optineurin in Antiviral Type I Interferon Production JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29755463 #FOAvip After a viral infection and the stimulation of some pattern-recognition receptors as the toll-like receptor 3 in the endosomes or the RIG-I-like receptors in the cytosol, activation of the IKK-related kinase TBK1 leads to the production of type I interferons (IFNs) after phosphorylation of the transcription factors IRF3 and IRF7. Recent findings indicate an involvement of K63-linked polyubiquitination and of the Golgi-localized protein optineurin (OPTN) in the activation of this crucial kinase involved in innate antiviral immunity. This review summarizes the sensing of viruses and the signaling leading to type I IFN production following TBK1 activation through its ubiquitination and the sensing of ubiquitin chains by OPTN at the Golgi apparatus. Twit Text FOAVip The Role of Optineurin in Antiviral Type I Interferon Production ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29755463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29755463 #FOAvip English Wikipedia <ref>{{Cite pmid|29755463}}</ref> The Role of Optineurin in Antiviral Type I Interferon Production #MMPMID29755463 Outlioua A; Pourcelot M; Arnoult D Front Immunol 2018[]; 9 (ä): ä PMID29755463show ga After a viral infection and the stimulation of some pattern-recognition receptors as the toll-like receptor 3 in the endosomes or the RIG-I-like receptors in the cytosol, activation of the IKK-related kinase TBK1 leads to the production of type I interferons (IFNs) after phosphorylation of the transcription factors IRF3 and IRF7. Recent findings indicate an involvement of K63-linked polyubiquitination and of the Golgi-localized protein optineurin (OPTN) in the activation of this crucial kinase involved in innate antiviral immunity. This review summarizes the sensing of viruses and the signaling leading to type I IFN production following TBK1 activation through its ubiquitination and the sensing of ubiquitin chains by OPTN at the Golgi apparatus. äThe Role of Optineurin in Antiviral Type I Interferon Production (epmc).pdf DeepDyve Pubget Overpricing