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10.1016/j.ekir.2017.10.004 http://scihub22266oqcxt.onion/10.1016/j.ekir.2017.10.004 C5932128!5932128 !29725632     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29725632 &cmd=llinks): Failed to open stream: HTTP request failed! 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Urinary Biomarkers to Identify Autosomal Dominant Polycystic Kidney Disease Patients With a High Likelihood of Disease Progression |pdf=|usr=}}{{29725632 }} gab.com Text Urinary Biomarkers to Identify Autosomal Dominant Polycystic Kidney Disease Patients With a High Likelihood of Disease Progression JO: Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29725632 #FOAvip INTRODUCTION: The variable disease course of autosomal dominant polycystic kidney disease (ADPKD) makes it important to develop biomarkers that can predict disease progression, from a patient perspective and to select patients for renoprotective treatment. We therefore investigated whether easy-to-measure urinary biomarkers are associated with disease progression and have additional value over that of conventional risk markers. METHODS: At baseline, inflammatory, glomerular, and tubular damage markers were measured in 24-hour urine collections (albumin, IgG, kidney injury molecule-1 (KIM-1), N-acetyl-?-d-glucosaminidase (NAG), ?2 microglobulin (?2MG), heart-type fatty acid binding protein (HFABP), macrophage migration inhibitory factor (MIF), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein-1 (MCP-1). Disease progression was expressed as annual change in estimated glomerular filtration rate (eGFR, Chronic Kidney Disease EPIdemiology equation), measured glomerular filtation rate (mGFR, using (125)I-iothalamate), or height-adjusted total kidney volume (htTKV). Multivariable linear regression was used to assess associations of these markers independent of conventional risk markers. RESULTS: A total of 104 ADPKD patients were included (40 ± 11 years, 39% female, eGFR 77 ± 30, mGFR 79 ± 30 ml/min per 1.73 m(2) and htTKV 852 [510-1244] ml/m). In particular, ?2MG and MCP-1 were associated with annual change in eGFR, and remained associated after adjustment for conventional risk markers (standardized ? = -0.35, P = 0.001, and standardized ? = -0.29, P = 0.009, respectively). Adding ?2MG and MCP-1 to a model containing conventional risk markers that explained annual change in eGFR significantly increased the performance of the model (final R(2)  = 0.152 vs. 0.292, P = 0.001). Essentially similar results were obtained when only patients with an eGFR ? 60 ml/min per 1.73 m(2) were selected, or when change in mGFR was studied. Associations with change in htTKV were less strong. CONCLUSION: Urinary ?2MG and MCP-1 excretion were both associated with GFR decline in ADPKD, and had added value beyond that of conventional risk markers. These markers therefore have the potential to serve as predictive tools for clinical practice. Twit Text FOAVip Urinary Biomarkers to Identify Autosomal Dominant Polycystic Kidney Disease Patients With a High Likelihood of Disease Progression ????Kidney Int Rep http://www.kidney.de/pget.php?&tw=1&pmid=29725632 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29725632 #FOAvip English Wikipedia <ref>{{Cite pmid|29725632 }}</ref> Urinary Biomarkers to Identify Autosomal Dominant Polycystic Kidney Disease Patients With a High Likelihood of Disease Progression #MMPMID29725632 Messchendorp AL ; Meijer E ; Boertien WE ; Engels GE ; Casteleijn NF ; Spithoven EM ; Losekoot M ; Burgerhof JGM ; Peters DJM ; Gansevoort RT Kidney Int Rep 2018[Mar]; 3 (2 ): 291-301 PMID29725632 show ga INTRODUCTION: The variable disease course of autosomal dominant polycystic kidney disease (ADPKD) makes it important to develop biomarkers that can predict disease progression, from a patient perspective and to select patients for renoprotective treatment. We therefore investigated whether easy-to-measure urinary biomarkers are associated with disease progression and have additional value over that of conventional risk markers. METHODS: At baseline, inflammatory, glomerular, and tubular damage markers were measured in 24-hour urine collections (albumin, IgG, kidney injury molecule-1 (KIM-1), N-acetyl-?-d-glucosaminidase (NAG), ?2 microglobulin (?2MG), heart-type fatty acid binding protein (HFABP), macrophage migration inhibitory factor (MIF), neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemotactic protein-1 (MCP-1). Disease progression was expressed as annual change in estimated glomerular filtration rate (eGFR, Chronic Kidney Disease EPIdemiology equation), measured glomerular filtation rate (mGFR, using (125)I-iothalamate), or height-adjusted total kidney volume (htTKV). Multivariable linear regression was used to assess associations of these markers independent of conventional risk markers. RESULTS: A total of 104 ADPKD patients were included (40 ± 11 years, 39% female, eGFR 77 ± 30, mGFR 79 ± 30 ml/min per 1.73 m(2) and htTKV 852 [510-1244] ml/m). In particular, ?2MG and MCP-1 were associated with annual change in eGFR, and remained associated after adjustment for conventional risk markers (standardized ? = -0.35, P = 0.001, and standardized ? = -0.29, P = 0.009, respectively). Adding ?2MG and MCP-1 to a model containing conventional risk markers that explained annual change in eGFR significantly increased the performance of the model (final R(2)  = 0.152 vs. 0.292, P = 0.001). Essentially similar results were obtained when only patients with an eGFR ? 60 ml/min per 1.73 m(2) were selected, or when change in mGFR was studied. Associations with change in htTKV were less strong. CONCLUSION: Urinary ?2MG and MCP-1 excretion were both associated with GFR decline in ADPKD, and had added value beyond that of conventional risk markers. These markers therefore have the potential to serve as predictive tools for clinical practice. äUrinary Biomarkers to Identify Autosomal Dominant Polycystic Kidney Di(epmc).pdf DeepDyve Pubget Overpricing