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10.1038/s41467-018-03750-7 http://scihub22266oqcxt.onion/10.1038/s41467-018-03750-7 C5931508!5931508 !29717110     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29717110 &cmd=llinks): Failed to open stream: HTTP request failed! 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IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE |pdf=|usr=}}{{29717110 }} gab.com Text IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29717110 #FOAvip Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c(hi)T-bet(+) B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11c(hi)T-bet(+) B cells and promote the differentiation of these cells into Ig-secreting autoreactive plasma cells. While murine studies have identified a role for T-bet-expressing B cells in autoimmunity, this study describes and exemplifies the importance of CD11c(hi)T-bet(+) B cells in human SLE. Twit Text FOAVip IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29717110 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29717110 #FOAvip English Wikipedia <ref>{{Cite pmid|29717110 }}</ref> IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE #MMPMID29717110 Wang S ; Wang J ; Kumar V ; Karnell JL ; Naiman B ; Gross PS ; Rahman S ; Zerrouki K ; Hanna R ; Morehouse C ; Holoweckyj N ; Liu H ; Manna Z ; Goldbach-Mansky R ; Hasni S ; Siegel R ; Sanjuan M ; Streicher K ; Cancro MP ; Kolbeck R ; Ettinger R Nat Commun 2018[May]; 9 (1 ): 1758 PMID29717110 show ga Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11c(hi)T-bet(+) B cell subset, with a unique expression profile including chemokine receptors consistent with migration to target tissues, is expanded in SLE patients, present in nephrotic kidney, enriched for autoreactive specificities and correlates with defined clinical manifestations. IL-21 can potently induce CD11c(hi)T-bet(+) B cells and promote the differentiation of these cells into Ig-secreting autoreactive plasma cells. While murine studies have identified a role for T-bet-expressing B cells in autoimmunity, this study describes and exemplifies the importance of CD11c(hi)T-bet(+) B cells in human SLE. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |B-Lymphocyte Subsets [MESH] |B-Lymphocytes/*immunology/metabolism [MESH] |CD11c Antigen/*immunology [MESH] |Cell Differentiation/*physiology [MESH] |Cohort Studies [MESH] |Female [MESH] |Humans [MESH] |Interleukin-21 [MESH] |Interleukins/*physiology [MESH] |Lupus Erythematosus, Systemic/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Plasma Cells/*cytology/immunology [MESH] |T-Box Domain Proteins/*metabolism [MESH]IL-21 drives expansion and plasma cell differentiation of autoreactive(epmc).pdf DeepDyve Pubget Overpricing