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10.1371/journal.pone.0195893 http://scihub22266oqcxt.onion/10.1371/journal.pone.0195893 C5931457!5931457!29718933     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (5): ä Nephropedia Template TP {{tp|p=29718933|t=2018. A20 regulates canonical wnt-signaling through an interaction with RIPK4 |pdf=|usr=}}{{29718933}} gab.com Text A20 regulates canonical wnt-signaling through an interaction with RIPK4 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29718933 #FOAvip A20 is a ubiquitin-editing enzyme that is known to regulate inflammatory signaling and cell death. However, A20 mutations are also frequently found in multiple malignancies suggesting a potential role as a tumor suppressor as well. We recently described a novel role for A20 in regulating the wnt-beta-catenin signaling pathway and suppressing colonic tumor development in mice. The underlying mechanisms for this phenomenon are unclear. To study this, we first generated A20 knockout cell lines by genome-editing techniques. Using these cells, we show that loss of A20 causes dysregulation of wnt-dependent gene expression by RNAseq. Mechanistically, A20 interacts with a proximal signaling component of the wnt-signaling pathway, receptor interacting protein kinase 4 (RIPK4), and regulation of wnt-signaling by A20 occurs through RIPK4. Finally, similar to the mechanism by which A20 regulates other members of the receptor interacting protein kinase family, A20 modifies ubiquitin chains on RIPK4 suggesting a possible molecular mechanism for A20?s control over the wnt-signaling pathway. Twit Text FOAVip A20 regulates canonical wnt-signaling through an interaction with RIPK4 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29718933 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29718933 #FOAvip English Wikipedia <ref>{{Cite pmid|29718933}}</ref> A20 regulates canonical wnt-signaling through an interaction with RIPK4 #MMPMID29718933 Nakamura BN; Glazier A; Kattah MG; Duong B; Jia Y; Campo D; Shao L PLoS One 2018[]; 13 (5): ä PMID29718933show ga A20 is a ubiquitin-editing enzyme that is known to regulate inflammatory signaling and cell death. However, A20 mutations are also frequently found in multiple malignancies suggesting a potential role as a tumor suppressor as well. We recently described a novel role for A20 in regulating the wnt-beta-catenin signaling pathway and suppressing colonic tumor development in mice. The underlying mechanisms for this phenomenon are unclear. To study this, we first generated A20 knockout cell lines by genome-editing techniques. Using these cells, we show that loss of A20 causes dysregulation of wnt-dependent gene expression by RNAseq. Mechanistically, A20 interacts with a proximal signaling component of the wnt-signaling pathway, receptor interacting protein kinase 4 (RIPK4), and regulation of wnt-signaling by A20 occurs through RIPK4. Finally, similar to the mechanism by which A20 regulates other members of the receptor interacting protein kinase family, A20 modifies ubiquitin chains on RIPK4 suggesting a possible molecular mechanism for A20?s control over the wnt-signaling pathway. äA20 regulates canonical wnt-signaling through an interaction with RIPK(epmc).pdf DeepDyve Pubget Overpricing