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10.2147/OTT.S163570 http://scihub22266oqcxt.onion/10.2147/OTT.S163570 C5931238!5931238!29740212     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2018 ; 11 (ä): 2363-73 Nephropedia Template TP {{tp|p=29740212|t=2018. LDH-Apromotes epithelial?mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer |pdf=|usr=}}{{29740212}} gab.com Text LDH-Apromotes epithelial mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29740212 #FOAvip Introduction: Epithelial-mesenchymal transition (EMT) is regarded as a crucial process of invasion and metastasis, which contribute greatly to cancer-related relapse and death. Based on research results that hypoxia can trigger gastric cancer EMT and decreasing lactate production can selectively kill hypoxic cancer cells, we infer that lactate dehydrogenase A (LDH-A) transforming pyruvate into lactate is at least in part responsible for poor prognosis of gastric cancer. Materials and methods: We used siRNA to knock down LDH-A in intestinal-type gastric cancer (ITGC) cell lines SGC7901 and BGC823. Western blot and RT-PCR were applied to detect mRNA and protein expression of EMT-related genes, respectively. Transwell invasion assay and migration assay were applied to study invasive and migratory abilities, respectively. Survival analysis was used to evaluate prognostic values. Results and conclusion: The results of in vitro experiment demonstrated that LDH-A facilitates ITGC cells? invasion and migration by upregulating ZEB2. The positive correlation between LDH-A and ZEB2 was verified in 371 ITGC specimens. Survival analysis indicated that co-expression of LDH-A/ZEB2 had synergetic power to predict overall survival. Thus, we conclude that the close relationship between LDH-A and ZEB2 may offer a potential therapeutic strategy for ITGC. Twit Text FOAVip LDH-Apromotes epithelial mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=29740212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29740212 #FOAvip English Wikipedia <ref>{{Cite pmid|29740212}}</ref> LDH-Apromotes epithelial?mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer #MMPMID29740212 Zhang Y; Lin S; Chen Y; Yang F; Liu S Onco Targets Ther 2018[]; 11 (ä): 2363-73 PMID29740212show ga Introduction: Epithelial-mesenchymal transition (EMT) is regarded as a crucial process of invasion and metastasis, which contribute greatly to cancer-related relapse and death. Based on research results that hypoxia can trigger gastric cancer EMT and decreasing lactate production can selectively kill hypoxic cancer cells, we infer that lactate dehydrogenase A (LDH-A) transforming pyruvate into lactate is at least in part responsible for poor prognosis of gastric cancer. Materials and methods: We used siRNA to knock down LDH-A in intestinal-type gastric cancer (ITGC) cell lines SGC7901 and BGC823. Western blot and RT-PCR were applied to detect mRNA and protein expression of EMT-related genes, respectively. Transwell invasion assay and migration assay were applied to study invasive and migratory abilities, respectively. Survival analysis was used to evaluate prognostic values. Results and conclusion: The results of in vitro experiment demonstrated that LDH-A facilitates ITGC cells? invasion and migration by upregulating ZEB2. The positive correlation between LDH-A and ZEB2 was verified in 371 ITGC specimens. Survival analysis indicated that co-expression of LDH-A/ZEB2 had synergetic power to predict overall survival. Thus, we conclude that the close relationship between LDH-A and ZEB2 may offer a potential therapeutic strategy for ITGC. äLDH-Apromotes epithelial?mesenchymal transition by upregulating ZEB2 i(epmc).pdf DeepDyve Pubget Overpricing