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10.1172/jci.insight.98240 http://scihub22266oqcxt.onion/10.1172/jci.insight.98240 C5931120!5931120!29669939     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29669939&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 3 (8): ä Nephropedia Template TP {{tp|p=29669939|t=ä. Cystic fibrosis?related diabetes is caused by islet loss and inflammation |pdf=|usr=}}{{29669939}} gab.com Text Cystic fibrosis related diabetes is caused by islet loss and inflammation JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29669939 #FOAvip Cystic fibrosis?related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of ? cell CFTR deletion and normal and CF human pancreas and islets. Specific deletion of CFTR from murine ? cells did not affect ? cell function. In human islets, CFTR mRNA was minimally expressed, and CFTR protein and electrical activity were not detected. Isolated CF/CFRD islets demonstrated appropriate insulin and glucagon secretion, with few changes in key islet-regulatory transcripts. Furthermore, approximately 65% of ? cell area was lost in CF donors, compounded by pancreatic remodeling and immune infiltration of the islet. These results indicate that CFRD is caused by ? cell loss and intraislet inflammation in the setting of a complex pleiotropic disease and not by intrinsic islet dysfunction from CFTR mutation. Twit Text FOAVip Cystic fibrosis related diabetes is caused by islet loss and inflammation ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29669939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29669939 #FOAvip English Wikipedia <ref>{{Cite pmid|29669939}}</ref> Cystic fibrosis?related diabetes is caused by islet loss and inflammation #MMPMID29669939 Hart NJ; Aramandla R; Poffenberger G; Fayolle C; Thames AH; Bautista A; Spigelman AF; Babon JAB; DeNicola ME; Dadi PK; Bush WS; Balamurugan AN; Brissova M; Dai C; Prasad N; Bottino R; Jacobson DA; Drumm ML; Kent SC; MacDonald PE; Powers AC JCI Insight ä[]; 3 (8): ä PMID29669939show ga Cystic fibrosis?related (CF-related) diabetes (CFRD) is an increasingly common and devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the underlying causes of CFRD are unclear. Here, we examined cystic fibrosis transmembrane conductance regulator (CFTR) islet expression and whether the CFTR participates in islet endocrine cell function using murine models of ? cell CFTR deletion and normal and CF human pancreas and islets. Specific deletion of CFTR from murine ? cells did not affect ? cell function. In human islets, CFTR mRNA was minimally expressed, and CFTR protein and electrical activity were not detected. Isolated CF/CFRD islets demonstrated appropriate insulin and glucagon secretion, with few changes in key islet-regulatory transcripts. Furthermore, approximately 65% of ? cell area was lost in CF donors, compounded by pancreatic remodeling and immune infiltration of the islet. These results indicate that CFRD is caused by ? cell loss and intraislet inflammation in the setting of a complex pleiotropic disease and not by intrinsic islet dysfunction from CFTR mutation. äCystic fibrosis?related diabetes is caused by islet loss and inflammat(epmc).pdf DeepDyve Pubget Overpricing