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10.1186/s13046-018-0766-7 http://scihub22266oqcxt.onion/10.1186/s13046-018-0766-7 C5930748!5930748!29716631     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Exp+Clin+Cancer+Res 2018 ; 37 (ä): ä Nephropedia Template TP {{tp|p=29716631|t=2018. NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma |pdf=|usr=}}{{29716631}} gab.com Text NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma JO: J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29716631 #FOAvip Background: Tumor microenvironment (TME) includes many factors such as tumor associated inflammatory cells, vessels, and lymphocytes, as well as different signaling molecules and extracellular matrix components. These aspects can be de-regulated and consequently lead to a worsening of cancer progression. In recent years an association between the scaffolding protein Na+/H+ exchanger regulatory factor 1 (NHERF1) and tumor microenvironment changes in breast cancer (BC) has been reported. Methods: Subcellular NHERF1 localization, vascular endothelial growth factor (VEGF), its receptor VEGFR1, hypoxia inducible factor 1 alpha (HIF-1?), TWIST1 expression and microvessel density (MVD) in 183 invasive BCs were evaluated, using immunohistochemistry on tissue microarrays (TMA). Immunofluorescence was employed to explore protein interactions. Results: Cytoplasmic NHERF1(cNHERF1) expression was directly related to cytoplasmic VEGF and VEGFR1 expression (p?=?0.001 and p?=?0.027 respectively), and inversely to nuclear HIF-1? (p?=?0.021) and TWIST1 (p?=?0.001). Further, immunofluorescence revealed an involvement of tumor cells with NHERF1 positive staining in neo-vascular formation, suggesting a ?mosaic? structure development of these neo-vessels. Survival analyses showed that loss of nuclear TWIST1 (nTWIST1) expression was related to a decrease of disease free survival (DFS) (p?<?0.001), while nTWIST1-/mNHERF1+ presented an increased DFS with respect to nTWIST1+/mNHERF1- phenotype (p?<?0.001). Subsequently, the analyses of nTWIST1+/cNHERF1+ phenotype selected a subgroup of patients with a worse DFS compared to nTWIST1-/cNHERF1- patients (p?=?0.004). Conclusion: Resulting data suggested a dynamic relation between NHERF1 and TME markers, and confirmed both the oncosuppressor role of membranous NHERF1 expression and the oncogene activity of cytoplasmic NHERF1. Electronic supplementary material: The online version of this article (10.1186/s13046-018-0766-7) contains supplementary material, which is available to authorized users. Twit Text FOAVip NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma ????J Exp Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=29716631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29716631 #FOAvip English Wikipedia <ref>{{Cite pmid|29716631}}</ref> NHERF1 and tumor microenvironment: a new scene in invasive breast carcinoma #MMPMID29716631 Saponaro C; Vagheggini A; Scarpi E; Centonze M; Catacchio I; Popescu O; Pastena MI; Giotta F; Silvestris N; Mangia A J Exp Clin Cancer Res 2018[]; 37 (ä): ä PMID29716631show ga Background: Tumor microenvironment (TME) includes many factors such as tumor associated inflammatory cells, vessels, and lymphocytes, as well as different signaling molecules and extracellular matrix components. These aspects can be de-regulated and consequently lead to a worsening of cancer progression. In recent years an association between the scaffolding protein Na+/H+ exchanger regulatory factor 1 (NHERF1) and tumor microenvironment changes in breast cancer (BC) has been reported. Methods: Subcellular NHERF1 localization, vascular endothelial growth factor (VEGF), its receptor VEGFR1, hypoxia inducible factor 1 alpha (HIF-1?), TWIST1 expression and microvessel density (MVD) in 183 invasive BCs were evaluated, using immunohistochemistry on tissue microarrays (TMA). Immunofluorescence was employed to explore protein interactions. Results: Cytoplasmic NHERF1(cNHERF1) expression was directly related to cytoplasmic VEGF and VEGFR1 expression (p?=?0.001 and p?=?0.027 respectively), and inversely to nuclear HIF-1? (p?=?0.021) and TWIST1 (p?=?0.001). Further, immunofluorescence revealed an involvement of tumor cells with NHERF1 positive staining in neo-vascular formation, suggesting a ?mosaic? structure development of these neo-vessels. Survival analyses showed that loss of nuclear TWIST1 (nTWIST1) expression was related to a decrease of disease free survival (DFS) (p? äNHERF1 and tumor microenvironment: a new scene in invasive breast carc(epmc).pdf DeepDyve Pubget Overpricing