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2018 ; 14
(4
): 398-405
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Tumor Necrosis Factor-? Induced Protein 8: Pathophysiology, Clinical
Significance, and Regulatory Mechanism
#MMPMID29725261
Zhang L
; Liu R
; Luan YY
; Yao YM
Int J Biol Sci
2018[]; 14
(4
): 398-405
PMID29725261
show ga
Tumor necrosis factor-?-induced protein-8 (TNFAIP8) is the earliest discovered
component of TNFAIP8 family [tumor necrosis factor-?-induced protein-8 like
(TIPE) family]. TNFAIP8 contains a putative death effector domain (DED)
homologous to DED II in FLIP (Fas-associated death domain-like
interleukin-1?-converting enzyme-inhibitory protein), which may affect cell
survival/death process. Recently, it has been demonstrated that TNFAIP8 could
inhibit apoptosis and autophagy in various types of cells. Moreover, TNFAIP8
level fluctuated evidently in patients with inflammatory, malignant, and
autoimmune diseases, indicating that it might be an anti-apoptotic and
oncogenetic protein. Herein we will review the discovery, gene/protein structure,
pathophysiological functions, and clinical significance of TNFAIP8 together with
its potential regulatory mechanism.