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10.1186/s12940-018-0387-9 http://scihub22266oqcxt.onion/10.1186/s12940-018-0387-9 C5930419!5930419!29720177     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29720177&cmd=llinks): Failed to open stream: HTTP request failed! 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Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers |pdf=|usr=}}{{29720177}} gab.com Text Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers JO: Environ Health http://www.kidney.de/pget.php?&tw=1&pmid=29720177 #FOAvip Background: Chronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow radiation doses. Current analysis aimed to clarify whether the increased risks were due to radiation or to genetic mutations in the Ukrainian population. Methods: A detailed characterization of the genomic landscape was performed in a unique sample of 16 UR-CLL patients and age- and sex-matched unexposed general population Ukrainian-CLL (UN-CLL) and Western-CLL (W-CLL) patients (n?=?28 and 100, respectively). Results: Mutations in telomere-maintenance pathway genes POT1 and ATM were more frequent in UR-CLL compared to UN-CLL and W-CLL (both p?<?0.05). No significant enrichment in copy-number abnormalities at del13q14, del11q, del17p or trisomy12 was identified in UR-CLL compared to other groups. Type of work performed in the Chornobyl zone, age at exposure and at diagnosis, calendar time, and Rai stage were significant predictors of total genetic lesions (all p?<?0.05). Tumor telomere length was significantly longer in UR-CLL than in UN-CLL (p?=?0.009) and was associated with the POT1 mutation and survival. Conclusions: No significant enrichment in copy-number abnormalities at CLL-associated genes was identified in UR-CLL compared to other groups. The novel associations between radiation exposure, telomere maintenance and CLL prognosis identified in this unique case series provide suggestive, though limited data and merit further investigation. Electronic supplementary material: The online version of this article (10.1186/s12940-018-0387-9) contains supplementary material, which is available to authorized users. Twit Text FOAVip Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers ????Environ Health http://www.kidney.de/pget.php?&tw=1&pmid=29720177 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29720177 #FOAvip English Wikipedia <ref>{{Cite pmid|29720177}}</ref> Genomic characterization of chronic lymphocytic leukemia (CLL) in radiation-exposed Chornobyl cleanup workers #MMPMID29720177 Ojha J; Dyagil I; Finch SC; Reiss RF; de Smith AJ; Gonseth S; Zhou M; Hansen HM; Sherborne AL; Nakamura J; Bracci PM; Gudzenko N; Hatch M; Babkina N; Little MP; Chumak VV; Walsh KM; Bazyka D; Wiemels JL; Zablotska LB Environ Health 2018[]; 17 (ä): ä PMID29720177show ga Background: Chronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow radiation doses. Current analysis aimed to clarify whether the increased risks were due to radiation or to genetic mutations in the Ukrainian population. Methods: A detailed characterization of the genomic landscape was performed in a unique sample of 16 UR-CLL patients and age- and sex-matched unexposed general population Ukrainian-CLL (UN-CLL) and Western-CLL (W-CLL) patients (n?=?28 and 100, respectively). Results: Mutations in telomere-maintenance pathway genes POT1 and ATM were more frequent in UR-CLL compared to UN-CLL and W-CLL (both p? äGenomic characterization of chronic lymphocytic leukemia (CLL) in radi(epmc).pdf DeepDyve Pubget Overpricing